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- W1469895763 abstract "Throughout pregnancy, hCG has numerous functions. hCG promotes progesterone production in corpus luteal cells. This endocrine action is limited, however, to the time of pregnancy implantation and the 3 weeks that follow (3–6 weeks of gestation). The progesterone produced during this period is needed to maintain the decidua and prevent menstrual bleeding. It also promotes angiogenesis in the maternal uterine vasculature so that uterine spiral arteries optimally meet with the implanting placenta. hCG suppresses the maternal immune system rejection of fetal and placental tissues, and inhibits myometrial contractions through the term of pregnancy. As the fetus grows, hCG promotes growth of the uterus, modifies myometrial smooth muscle tissues, and prepares decidual and myometrial tissues for reception of trophoblast cells. It also promotes the differentiation of mononuclear cytotrophoblast cells to polynuclear syncytiotrophoblast cells, which are the functional cells of the maternal–fetal circulation barrier. hCG also has functions during pregnancy in growth and differentiation of fetal organs. Interestingly, this hCG receptor disappears in the adult. The combination of hCG-H and hCG may lead to cytotrophoblast growth and differentiation, or together to placenta growth and trophoblastic villi. Armed with the knowledge of this hCG and hCG-H production and function information, this chapter examines the overall processes of implantation and placentation in humans." @default.
- W1469895763 created "2016-06-24" @default.
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- W1469895763 date "2010-01-01" @default.
- W1469895763 modified "2023-09-26" @default.
- W1469895763 title "Introduction to Pregnancy Implantation, Villous Formation, and Hemochorial Placentation" @default.
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- W1469895763 doi "https://doi.org/10.1016/b978-0-12-384907-6.00003-7" @default.
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