Matches in SemOpenAlex for { <https://semopenalex.org/work/W147061710> ?p ?o ?g. }
- W147061710 abstract "Abstract Non-muscle myosin II role has been implicated in the extension of lamellipodia, a critical step in the initiation of directed cell migration, invasion and other cellular processes, but the mechanistic details are limited to driving retrograde actin filaments. The present study reveals distinct localization of myosin IIA and IIB with an unexpected opposite mechanical roles in mediating lamellipodia extension during spreading. Attachment of cells to matrix is impaired in the absence of either isoforms, but differential regulation of focal contacts formation occurs in myosin IIA^-^; and IIB^-^; cells. Spreading cells expressing both isoforms display an organized actin network consisting of retrograde filaments, arcs and central filaments. Loss of actin arcs and central filaments occurs upon depletion of either myosin IIA or IIB, but myosin IIB^-^; cells displayed long parallel actin filaments elongated from cell edge. From these studies, a model for myosin IIA and IIB with separate, but linked mechanical roles in mediating lamellipodia extension is developed." @default.
- W147061710 created "2016-06-24" @default.
- W147061710 creator A5080808334 @default.
- W147061710 date "2009-02-18" @default.
- W147061710 modified "2023-10-16" @default.
- W147061710 title "Myosin II isoforms with separate but linked functions determine the fate of lamellipodia extension during cell spreading" @default.
- W147061710 cites W1966543080 @default.
- W147061710 cites W1967265143 @default.
- W147061710 cites W1969641665 @default.
- W147061710 cites W1971106165 @default.
- W147061710 cites W1979038578 @default.
- W147061710 cites W1983281158 @default.
- W147061710 cites W1985042934 @default.
- W147061710 cites W1985230755 @default.
- W147061710 cites W1987139499 @default.
- W147061710 cites W2009234826 @default.
- W147061710 cites W2009540102 @default.
- W147061710 cites W2013384706 @default.
- W147061710 cites W2015943575 @default.
- W147061710 cites W2016651900 @default.
- W147061710 cites W2022395779 @default.
- W147061710 cites W2031506032 @default.
- W147061710 cites W2033897003 @default.
- W147061710 cites W2035207820 @default.
- W147061710 cites W2048597432 @default.
- W147061710 cites W2050612706 @default.
- W147061710 cites W2060661444 @default.
- W147061710 cites W2071967573 @default.
- W147061710 cites W2073375166 @default.
- W147061710 cites W2073891485 @default.
- W147061710 cites W2074812494 @default.
- W147061710 cites W2077255555 @default.
- W147061710 cites W2078366377 @default.
- W147061710 cites W2088265369 @default.
- W147061710 cites W2089920144 @default.
- W147061710 cites W2093488327 @default.
- W147061710 cites W2103446130 @default.
- W147061710 cites W2105416994 @default.
- W147061710 cites W2105630915 @default.
- W147061710 cites W2111719518 @default.
- W147061710 cites W2113657260 @default.
- W147061710 cites W2116899346 @default.
- W147061710 cites W2117395405 @default.
- W147061710 cites W2120087236 @default.
- W147061710 cites W2126496496 @default.
- W147061710 cites W2130332090 @default.
- W147061710 cites W2138777762 @default.
- W147061710 cites W2147195519 @default.
- W147061710 cites W2149618351 @default.
- W147061710 cites W2150841569 @default.
- W147061710 cites W2153175562 @default.
- W147061710 cites W2154589602 @default.
- W147061710 cites W2154929572 @default.
- W147061710 cites W2163321146 @default.
- W147061710 cites W2165722121 @default.
- W147061710 cites W2165972241 @default.
- W147061710 doi "https://doi.org/10.1038/npre.2009.2868.1" @default.
- W147061710 hasPublicationYear "2009" @default.
- W147061710 type Work @default.
- W147061710 sameAs 147061710 @default.
- W147061710 citedByCount "0" @default.
- W147061710 crossrefType "journal-article" @default.
- W147061710 hasAuthorship W147061710A5080808334 @default.
- W147061710 hasBestOaLocation W1470617101 @default.
- W147061710 hasConcept C104317684 @default.
- W147061710 hasConcept C109185818 @default.
- W147061710 hasConcept C12554922 @default.
- W147061710 hasConcept C125705527 @default.
- W147061710 hasConcept C137738243 @default.
- W147061710 hasConcept C1491633281 @default.
- W147061710 hasConcept C185592680 @default.
- W147061710 hasConcept C53345823 @default.
- W147061710 hasConcept C55493867 @default.
- W147061710 hasConcept C6997183 @default.
- W147061710 hasConcept C86803240 @default.
- W147061710 hasConcept C95444343 @default.
- W147061710 hasConceptScore W147061710C104317684 @default.
- W147061710 hasConceptScore W147061710C109185818 @default.
- W147061710 hasConceptScore W147061710C12554922 @default.
- W147061710 hasConceptScore W147061710C125705527 @default.
- W147061710 hasConceptScore W147061710C137738243 @default.
- W147061710 hasConceptScore W147061710C1491633281 @default.
- W147061710 hasConceptScore W147061710C185592680 @default.
- W147061710 hasConceptScore W147061710C53345823 @default.
- W147061710 hasConceptScore W147061710C55493867 @default.
- W147061710 hasConceptScore W147061710C6997183 @default.
- W147061710 hasConceptScore W147061710C86803240 @default.
- W147061710 hasConceptScore W147061710C95444343 @default.
- W147061710 hasLocation W1470617101 @default.
- W147061710 hasOpenAccess W147061710 @default.
- W147061710 hasPrimaryLocation W1470617101 @default.
- W147061710 hasRelatedWork W1582288217 @default.
- W147061710 hasRelatedWork W172711315 @default.
- W147061710 hasRelatedWork W1977978400 @default.
- W147061710 hasRelatedWork W2013143984 @default.
- W147061710 hasRelatedWork W2015982738 @default.
- W147061710 hasRelatedWork W2050566209 @default.
- W147061710 hasRelatedWork W2063158213 @default.
- W147061710 hasRelatedWork W2115143599 @default.
- W147061710 hasRelatedWork W2292845959 @default.