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• W1470758466 abstract "We have identified a novel cDNA encoding a protein (named TX) with > 50% overall sequence identity with the interleukin-1 beta converting enzyme (ICE) and approximately 30% sequence identity with the ICE homologs NEDD-2/ICH-1L and CED-3. A computer homology model of TX was constructed based on the X-ray coordinates of the ICE crystal recently published. This model suggests that TX is a cysteine protease, with the P1 aspartic acid substrate specificity retained. Transfection experiments demonstrate that TX is a protease which is able to cleave itself and the p30 ICE precursor, but not to generate mature IL-1 beta from pro-IL-1 beta. In addition, this protein induces apoptosis in transfected COS cells. TX therefore delineates a new member of the growing Ice/ced-3 gene family coding for proteases with cytokine processing activity or involved in programmed cell death." @default.
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• W1470758466 date "1995-05-01" @default.
• W1470758466 modified "2023-10-15" @default.
• W1470758466 title "A novel human protease similar to the interleukin-1 beta converting enzyme induces apoptosis in transfected cells." @default.
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• W1470758466 doi "https://doi.org/10.1002/j.1460-2075.1995.tb07183.x" @default.
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