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- W147134429 abstract "Cloning the nuclear polymerase gene has allowed identification of a number of sequence motifs that mediate nuclear targeting of the protein and DNA strand break recognition, to which the catalytic activity of the enzyme is linked. de Murcia and colleagues have pointed out how detailed structural information from the crystallized protein will eventually facilitate an understanding of the mechanism of poly(ADP-ribose) polymerase activation by DNA strand breaks. The availability of gene sequences that can be used as probes is facilitating studies on the expression of the gene in a variety of tissues under different physiological circumstances. It is also facilitating polymerase gene cloning from a growing variety of living organisms, thus enabling informed comment about the evolution of the gene." @default.
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- W147134429 date "1995-01-01" @default.
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- W147134429 title "Chapter 13 ADP-ribosylation reactions" @default.
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- W147134429 doi "https://doi.org/10.1016/s1569-2582(06)80015-2" @default.
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