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- W147182483 abstract "Multiple myeloma is incurable, and novel therapies are urgently needed. The proteasome inhibitor bortezomib targets both the tumor cell and the bone marrow microenvironment to overcome drug resistance in preclinical in vitro and in vivo models of human multiple myeloma. A recently completed phase II trial of bortezomib demonstrated durable responses and associated clinical benefit in patients with relapsed refractory myeloma, providing the basis for its Food and Drug Administration approval. Ongoing studies are evaluating bortezomib, alone and in combination, to treat patients earlier in the disease course.Key WordsProteasome inhibitormultiple myelomarefractory relapsed diseasesalvage therapy" @default.
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- W147182483 date "2004-01-01" @default.
- W147182483 modified "2023-10-14" @default.
- W147182483 title "Phase II Trials of Bortezomib for the Treatment of Multiple Myeloma" @default.
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- W147182483 doi "https://doi.org/10.1007/978-1-59259-794-9_22" @default.
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