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- W1473605636 abstract "OBJECTIVE: To report a rare case of bilateral acute retinal necrosis in the setting of varicella-zoster vasculopathy and review the related literature. BACKGROUND: Acute retinal necrosis in the setting of VZV vasculopathy is a rare entity. DESIGN/METHODS: Case Report. RESULTS: An 82-year-old male presented with acute and rapid progressive vision loss OU. Dilated fundoscopic examination demonstrated attenuated vessels, peripapillary hemorrhage, and diffuse retinal edema and hemorrhage generally sparing the macula OU, with superior retinal detachment OS. Serial MRI brain scans demonstrated T2-hyperintensities involving the bilateral optic nerves, spreading through the optic tracts to the lateral geniculate bodies. Initial serological and CSF studies were negative. Vision loss progressed to no light perception OU over 7 days. Biopsy of a lower extremity rash demonstrated positive PCR for varicella-zoster virus (VZV) prompting a 10-day course of valacyclovir. A left periventricular brain biopsy demonstrated ependymal lining with grey and white matter focal necrosis, inflammation and reactive changes suggestive of viral and/or non-viral vasculopathy. PCR test for varicella-zoster virus in fresh brain was positive. CONCLUSIONS: Acute retinal necrosis in the setting of VZV vasculopathy is a rare entity; however, this should be considered in cases of rapid bilateral vision loss with progressive changes along the pre- and post-chiasmal pathways on MRI, as early treatment may improve clinical outcomes. Disclosure: Dr. Saeed has nothing to disclose. Dr. Kaufman has nothing to disclose. Dr. Eggenberger has received personal compensation for activities with Biogen Idec, Genzyme, Questcor, Novartis, Acorda, Prime Pharma, Allergan, Inc. and Teva. Dr. Eggenberger has received research support from Teva, Allergan, Inc., Serono, and Berlex." @default.
- W1473605636 created "2016-06-24" @default.
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- W1473605636 date "2015-04-06" @default.
- W1473605636 modified "2023-09-27" @default.
- W1473605636 title "Acute Retinal Necrosis in the Setting of Varicella Zoster Vasculopathy - Case Report & Review of Literature (P5.301)" @default.
- W1473605636 hasPublicationYear "2015" @default.
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