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• W147471776 abstract "Research Article15 April 1996free access Yeast SUB1 is a suppressor of TFIIB mutations and has homology to the human co-activator PC4. R. Knaus R. Knaus Department of Biology, MIT, Cambridge 02139, USA. Search for more papers by this author R. Pollock R. Pollock Department of Biology, MIT, Cambridge 02139, USA. Search for more papers by this author L. Guarente L. Guarente Department of Biology, MIT, Cambridge 02139, USA. Search for more papers by this author R. Knaus R. Knaus Department of Biology, MIT, Cambridge 02139, USA. Search for more papers by this author R. Pollock R. Pollock Department of Biology, MIT, Cambridge 02139, USA. Search for more papers by this author L. Guarente L. Guarente Department of Biology, MIT, Cambridge 02139, USA. Search for more papers by this author Author Information R. Knaus1, R. Pollock1 and L. Guarente1 1Department of Biology, MIT, Cambridge 02139, USA. The EMBO Journal (1996)15:1933-1940https://doi.org/10.1002/j.1460-2075.1996.tb00544.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info Activation of transcription in eukaryotes depends upon the interplay between transcriptional activators and general transcription factors. While direct contacts between activators and general factors have been demonstrated in vitro, an additional class of proteins, termed co-activators, is also required of transcriptional activation. Here we describe a yeast protein, SUB1, that was isolated as a suppressor of the cold-sensitive TFIIB R78H mutant. The N-terminal third of SUB1 is highly similar to the mammalian co-activator PC4. We show that increased expression of SUB1 suppresses two alleles of TFIIB (E62G, R78H) specifically and that the deletion of SUB1 is lethal in combination with these same two alleles. We show that SUB1 binds to TFIIB in vitro and that it specifically inhibits the formation of TBP-TFIIB-promoter complexes. Furthermore we show that increasing the copy number of SUB1 stimulates transcriptional activation in vivo. Based on our results and recent observations of others, we propose that SUB1 plays a role in the release of TFIIB from the transcription complex during transcription initiation. Previous ArticleNext Article Volume 15Issue 81 April 1996In this issue RelatedDetailsLoading ..." @default.
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• W147471776 title "Yeast SUB1 is a suppressor of TFIIB mutations and has homology to the human co-activator PC4." @default.
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• W147471776 doi "https://doi.org/10.1002/j.1460-2075.1996.tb00544.x" @default.
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