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- W14752123 abstract "This chapter explores microarray technology and its potential to identify a large number of the genes/promoters affected by the environmental stimulus or the regulatory protein, or RNA. It discusses the new experimental, statistical, and computational methods that are expected to improve the technique, but may not resolve all issues. Ultimately, each candidate gene or promoter has to be confirmed directly. Study of the marA, soxS, and rob regulons of Escherichia coli illustrates the approach for using microarray results. These regulons are highly overlapping because the transcriptional activators that directly control them—MarA, SoxS, and Rob—are highly homologous and are bound with roughly similar affinities to a 20-bp asymmetric degenerate sequence. The chapter reviews the data that was pooled from three microarray conditions which used arrays from the same manufacturer, and followed similar protocols." @default.
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- W14752123 date "2003-01-01" @default.
- W14752123 modified "2023-10-16" @default.
- W14752123 title "Analysis of Microarray Data for the marA, soxS, and rob Regulons of Escherichia coli" @default.
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- W14752123 doi "https://doi.org/10.1016/s0076-6879(03)70024-x" @default.
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