FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1475263412> ?p ?o ?g. }

• W1475263412 endingPage "785" @default.
• W1475263412 startingPage "781" @default.
• W1475263412 abstract "Tat is a potent trans-activating protein encoded by the HIV genome. It is essential for viral replication, but has pleiotropic effects on host cells as well. We demonstrated that exogenous recombinant Tat increases immunoglobulin (Ig) and interleukin 6 (IL-6) production in vitro by normal uninfected peripheral blood mononuclear cells by 100-500%. The optimal Tat concentration was 100 ng/ml, but even a low concentration of 1 ng/ml induced a response in most subjects. The observed induction was inhibited by monoclonal anti-Tat antibodies and 2,3-dimercapto-1-propanol. Both anti-IL-6 antibodies and IL-6 antisense oligonucleotides inhibited Tat-induced IgG and IgA synthesis to some degree, whereas induction of IgM appeared to be independent of IL-6. We conclude that Tat can function in vitro in the absence of any other viral structures and induce Ig and IL-6 production; the clinical significance of these findings remains as yet undetermined." @default.
• W1475263412 created "2016-06-24" @default.
• W1475263412 creator A5005045340 @default.
• W1475263412 creator A5018323898 @default.
• W1475263412 creator A5036185134 @default.
• W1475263412 creator A5040821185 @default.
• W1475263412 date "1994-07-01" @default.
• W1475263412 modified "2023-10-18" @default.
• W1475263412 title "HIV Type 1 Tat Protein Induces Immunoglobulin and Interleukin 6 Synthesis by Uninfected Peripheral Blood Mononuclear Cells" @default.
• W1475263412 cites W1507250903 @default.
• W1475263412 cites W1518009762 @default.
• W1475263412 cites W1604626968 @default.
• W1475263412 cites W1790169325 @default.
• W1475263412 cites W1866708666 @default.
• W1475263412 cites W1928589437 @default.
• W1475263412 cites W1937757791 @default.
• W1475263412 cites W1960162449 @default.
• W1475263412 cites W1967737680 @default.
• W1475263412 cites W1979861012 @default.
• W1475263412 cites W1983546572 @default.
• W1475263412 cites W1998421163 @default.
• W1475263412 cites W2003847492 @default.
• W1475263412 cites W2008776444 @default.
• W1475263412 cites W2016328587 @default.
• W1475263412 cites W2035875570 @default.
• W1475263412 cites W205758415 @default.
• W1475263412 cites W2064914230 @default.
• W1475263412 cites W2074681297 @default.
• W1475263412 cites W2078406153 @default.
• W1475263412 cites W2079335891 @default.
• W1475263412 cites W2085437500 @default.
• W1475263412 cites W2116344911 @default.
• W1475263412 cites W2161430263 @default.
• W1475263412 cites W2180476901 @default.
• W1475263412 cites W4299401993 @default.
• W1475263412 doi "https://doi.org/10.1089/aid.1994.10.781" @default.
• W1475263412 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7986583" @default.
• W1475263412 hasPublicationYear "1994" @default.
• W1475263412 type Work @default.
• W1475263412 sameAs 1475263412 @default.
• W1475263412 citedByCount "41" @default.
• W1475263412 countsByYear W14752634122012 @default.
• W1475263412 countsByYear W14752634122014 @default.
• W1475263412 crossrefType "journal-article" @default.
• W1475263412 hasAuthorship W1475263412A5005045340 @default.
• W1475263412 hasAuthorship W1475263412A5018323898 @default.
• W1475263412 hasAuthorship W1475263412A5036185134 @default.
• W1475263412 hasAuthorship W1475263412A5040821185 @default.
• W1475263412 hasConcept C104317684 @default.
• W1475263412 hasConcept C129312508 @default.
• W1475263412 hasConcept C137061746 @default.
• W1475263412 hasConcept C153911025 @default.
• W1475263412 hasConcept C159047783 @default.
• W1475263412 hasConcept C159654299 @default.
• W1475263412 hasConcept C191732599 @default.
• W1475263412 hasConcept C202751555 @default.
• W1475263412 hasConcept C203014093 @default.
• W1475263412 hasConcept C2522874641 @default.
• W1475263412 hasConcept C2778690821 @default.
• W1475263412 hasConcept C40767141 @default.
• W1475263412 hasConcept C542903549 @default.
• W1475263412 hasConcept C55493867 @default.
• W1475263412 hasConcept C6881719 @default.
• W1475263412 hasConcept C74172505 @default.
• W1475263412 hasConcept C86803240 @default.
• W1475263412 hasConceptScore W1475263412C104317684 @default.
• W1475263412 hasConceptScore W1475263412C129312508 @default.
• W1475263412 hasConceptScore W1475263412C137061746 @default.
• W1475263412 hasConceptScore W1475263412C153911025 @default.
• W1475263412 hasConceptScore W1475263412C159047783 @default.
• W1475263412 hasConceptScore W1475263412C159654299 @default.
• W1475263412 hasConceptScore W1475263412C191732599 @default.
• W1475263412 hasConceptScore W1475263412C202751555 @default.
• W1475263412 hasConceptScore W1475263412C203014093 @default.
• W1475263412 hasConceptScore W1475263412C2522874641 @default.
• W1475263412 hasConceptScore W1475263412C2778690821 @default.
• W1475263412 hasConceptScore W1475263412C40767141 @default.
• W1475263412 hasConceptScore W1475263412C542903549 @default.
• W1475263412 hasConceptScore W1475263412C55493867 @default.
• W1475263412 hasConceptScore W1475263412C6881719 @default.
• W1475263412 hasConceptScore W1475263412C74172505 @default.
• W1475263412 hasConceptScore W1475263412C86803240 @default.
• W1475263412 hasIssue "7" @default.
• W1475263412 hasLocation W14752634121 @default.
• W1475263412 hasLocation W14752634122 @default.
• W1475263412 hasOpenAccess W1475263412 @default.
• W1475263412 hasPrimaryLocation W14752634121 @default.
• W1475263412 hasRelatedWork W1963847618 @default.
• W1475263412 hasRelatedWork W2181283348 @default.
• W1475263412 hasRelatedWork W2343297415 @default.
• W1475263412 hasRelatedWork W2368460920 @default.
• W1475263412 hasRelatedWork W2380360044 @default.
• W1475263412 hasRelatedWork W2380817849 @default.
• W1475263412 hasRelatedWork W2386779757 @default.
• W1475263412 hasRelatedWork W2415531140 @default.
• W1475263412 hasRelatedWork W2429425663 @default.
• W1475263412 hasRelatedWork W2976520252 @default.
• W1475263412 hasVolume "10" @default.

• next