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• W1476281311 abstract "Abstract We used a proteomics approach (iTRAQ) to identify differentially expressed lung proteins during early stages of the tobacco carcinogen, NNK-induced lung tumorigenesis (hyperplasia/atypia, 4–10 weeks and adenoma, 25 week) prior to the detection of adenocarcinoma in A/J mice. We identified 790 proteins at week 4 and 710 proteins at weeks 10 and 25 with >95% confidence and a Local False Discovery Rate estimation less than 5%. We have demonstrated that NNK altered multiple protein (e.g., Carbonyl Reductase, Annexin A5/6, Selenbp1, Hmgb1 and Hsp90b1) expressions in early lesions which can be used as potential biomarkers for early detection of lung cancer." @default.
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• W1476281311 date "2015-12-01" @default.
• W1476281311 modified "2023-09-27" @default.
• W1476281311 title "Proteomic profiling of hyperplasia/atypia and adenoma-induced by NNK in mouse lung identified multiple proteins as potential biomarkers for early detection" @default.
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• W1476281311 doi "https://doi.org/10.1016/j.euprot.2015.07.015" @default.
• W1476281311 hasPublicationYear "2015" @default.
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