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- W147652893 abstract "Hypertension exerts a dramatic toll on left ventricular performance and may contribute to clinical left ventricular dysfunction in 90% of patients with heart failure. In certain patient populations, hypertension may be the sole cause of left ventricular dysfunction in over 50% of patients affected by heart failure. This is most evident in the African American community where hypertensive heart disease is presumed to be the leading cause of left ventricular dysfunction. The expression of hypertensive heart disease is varied. Hypertension is a known risk factor for ischemic heart disease which leads to myocardial infarction and cell death. Left ventricular hypertrophy appears to be a definite risk factor for clinical left ventricular dysfunction. There appears to be a progression of disease from asymptomatic systemic hypertension to left ventricular hypertrophy, followed by diastolic dysfunction and subsequently systolic dysfunction. The majority of patients with hypertension do not develop left ventricular hypertrophy suggesting that in those affected there is a more permissive environment to promote hypertrophy (heart thickening). A mosaic of genetic, physiological and behavioral factors all interplay to lead to left ventricular hypertrophy. However the conversion from left ventricular hypertrophy to left ventricular systolic dysfunction is not well understood. Exemplary cases of systolic and diastolic dysfunction will be reviewed and an introduction to potential mechanisms that mediate the conversion from left ventricular hypertrophy to left ventricular systolic dysfunction will be introduced." @default.
- W147652893 created "2016-06-24" @default.
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- W147652893 date "2001-11-01" @default.
- W147652893 modified "2023-09-24" @default.
- W147652893 title "Hypertension and left ventricular function: case studies" @default.
- W147652893 doi "https://doi.org/10.1016/s0895-7061(01)02062-3" @default.
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