FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1476588> ?p ?o ?g. }

• W1476588 endingPage "1824" @default.
• W1476588 startingPage "1815" @default.
• W1476588 abstract "Colorectal cancer progression involves changes in phenotype and genotype. Although usually illustrated as a linear process, more complex underlying pathways have not been excluded. The object of this paper is to apply modern quantitative principles of molecular evolution to multistep tumor progression. To reconstruct progression lineages, the genotypes of two adjacent adenoma-cancer pairs were determined by serial dilution and polymerase chain reaction at 28-30 microsatellite (MS) loci and then traced back to their most recent common ancestor. The tumors were mismatch repair deficient, and therefore relatively large numbers of MS mutations should accumulate during progression. As expected, the MS genotypes were similar (correlation coefficients >0.9) between different parts of the same adenoma or cancer, but very different (correlation coefficients <0. 2) between unrelated metachronous adenoma-cancer pairs. Unexpectedly, the genotypes of the adjacent adenoma-cancer pairs were also very different (correlation coefficients of 0.30 and 0.36), consistent with early adenoma-cancer divergence rather than direct linear progression. More than 60% of the divisions occurred after this early adenoma-cancer divergence. Therefore, the tumor phylogenies were not consistent with sequential stepwise selection along a single most fit and frequent lineage from adenoma to cancer. Instead, one effective early progression strategy creates and maintains multiple evolving candidate lineages, which are subsequently selected for terminal clonal expansion." @default.
• W1476588 created "2016-06-24" @default.
• W1476588 creator A5010741320 @default.
• W1476588 creator A5026666281 @default.
• W1476588 creator A5028122006 @default.
• W1476588 creator A5028725974 @default.
• W1476588 creator A5058999096 @default.
• W1476588 creator A5067366828 @default.
• W1476588 date "1999-06-01" @default.
• W1476588 modified "2023-10-17" @default.
• W1476588 title "Colorectal Adenoma and Cancer Divergence" @default.
• W1476588 cites W105773406 @default.
• W1476588 cites W1483108766 @default.
• W1476588 cites W1489123075 @default.
• W1476588 cites W1533555842 @default.
• W1476588 cites W1817423755 @default.
• W1476588 cites W1839788593 @default.
• W1476588 cites W1894632965 @default.
• W1476588 cites W1907733689 @default.
• W1476588 cites W1964129698 @default.
• W1476588 cites W1967304777 @default.
• W1476588 cites W1977212112 @default.
• W1476588 cites W1978626016 @default.
• W1476588 cites W1978871519 @default.
• W1476588 cites W1998947396 @default.
• W1476588 cites W2001258296 @default.
• W1476588 cites W2003448413 @default.
• W1476588 cites W2011719683 @default.
• W1476588 cites W2015393776 @default.
• W1476588 cites W2019249381 @default.
• W1476588 cites W2024419615 @default.
• W1476588 cites W2033600479 @default.
• W1476588 cites W2065423665 @default.
• W1476588 cites W2080308138 @default.
• W1476588 cites W2091723114 @default.
• W1476588 cites W2093531978 @default.
• W1476588 cites W2101898337 @default.
• W1476588 cites W2131681278 @default.
• W1476588 cites W2132297696 @default.
• W1476588 cites W2218232968 @default.
• W1476588 cites W2322672979 @default.
• W1476588 cites W2189261185 @default.
• W1476588 doi "https://doi.org/10.1016/s0002-9440(10)65437-5" @default.
• W1476588 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2222548" @default.
• W1476588 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10362806" @default.
• W1476588 hasPublicationYear "1999" @default.
• W1476588 type Work @default.
• W1476588 sameAs 1476588 @default.
• W1476588 citedByCount "62" @default.
• W1476588 countsByYear W14765882012 @default.
• W1476588 countsByYear W14765882013 @default.
• W1476588 countsByYear W14765882014 @default.
• W1476588 countsByYear W14765882016 @default.
• W1476588 countsByYear W14765882017 @default.
• W1476588 countsByYear W14765882018 @default.
• W1476588 countsByYear W14765882019 @default.
• W1476588 countsByYear W14765882021 @default.
• W1476588 countsByYear W14765882022 @default.
• W1476588 crossrefType "journal-article" @default.
• W1476588 hasAuthorship W1476588A5010741320 @default.
• W1476588 hasAuthorship W1476588A5026666281 @default.
• W1476588 hasAuthorship W1476588A5028122006 @default.
• W1476588 hasAuthorship W1476588A5028725974 @default.
• W1476588 hasAuthorship W1476588A5058999096 @default.
• W1476588 hasAuthorship W1476588A5067366828 @default.
• W1476588 hasBestOaLocation W14765881 @default.
• W1476588 hasConcept C104317684 @default.
• W1476588 hasConcept C113968399 @default.
• W1476588 hasConcept C121608353 @default.
• W1476588 hasConcept C135763542 @default.
• W1476588 hasConcept C142724271 @default.
• W1476588 hasConcept C2777428134 @default.
• W1476588 hasConcept C2779256057 @default.
• W1476588 hasConcept C526805850 @default.
• W1476588 hasConcept C54355233 @default.
• W1476588 hasConcept C71924100 @default.
• W1476588 hasConcept C86803240 @default.
• W1476588 hasConceptScore W1476588C104317684 @default.
• W1476588 hasConceptScore W1476588C113968399 @default.
• W1476588 hasConceptScore W1476588C121608353 @default.
• W1476588 hasConceptScore W1476588C135763542 @default.
• W1476588 hasConceptScore W1476588C142724271 @default.
• W1476588 hasConceptScore W1476588C2777428134 @default.
• W1476588 hasConceptScore W1476588C2779256057 @default.
• W1476588 hasConceptScore W1476588C526805850 @default.
• W1476588 hasConceptScore W1476588C54355233 @default.
• W1476588 hasConceptScore W1476588C71924100 @default.
• W1476588 hasConceptScore W1476588C86803240 @default.
• W1476588 hasIssue "6" @default.
• W1476588 hasLocation W14765881 @default.
• W1476588 hasLocation W14765882 @default.
• W1476588 hasLocation W14765883 @default.
• W1476588 hasLocation W14765884 @default.
• W1476588 hasOpenAccess W1476588 @default.
• W1476588 hasPrimaryLocation W14765881 @default.
• W1476588 hasRelatedWork W1476588 @default.
• W1476588 hasRelatedWork W1991523530 @default.
• W1476588 hasRelatedWork W2002128513 @default.

• next