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• W1477929837 abstract "Research Article15 September 1994free access Developmental rescue of an embryonic-lethal mutation in the retinoblastoma gene in chimeric mice. E.C. Maandag E.C. Maandag Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam. Search for more papers by this author M. van der Valk M. van der Valk Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam. Search for more papers by this author M. Vlaar M. Vlaar Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam. Search for more papers by this author C. Feltkamp C. Feltkamp Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam. Search for more papers by this author J. O'Brien J. O'Brien Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam. Search for more papers by this author M. van Roon M. van Roon Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam. Search for more papers by this author N. van der Lugt N. van der Lugt Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam. Search for more papers by this author A. Berns A. Berns Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam. Search for more papers by this author H. te Riele H. te Riele Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam. Search for more papers by this author E.C. Maandag E.C. Maandag Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam. Search for more papers by this author M. van der Valk M. van der Valk Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam. Search for more papers by this author M. Vlaar M. Vlaar Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam. Search for more papers by this author C. Feltkamp C. Feltkamp Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam. Search for more papers by this author J. O'Brien J. O'Brien Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam. Search for more papers by this author M. van Roon M. van Roon Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam. Search for more papers by this author N. van der Lugt N. van der Lugt Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam. Search for more papers by this author A. Berns A. Berns Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam. Search for more papers by this author H. te Riele H. te Riele Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam. Search for more papers by this author Author Information E.C. Maandag1, M. Valk1, M. Vlaar1, C. Feltkamp1, J. O'Brien1, M. Roon1, N. Lugt1, A. Berns1 and H. Riele1 1Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam. The EMBO Journal (1994)13:4260-4268https://doi.org/10.1002/j.1460-2075.1994.tb06746.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info The requirement for a functional retinoblastoma gene, Rb-1, in murine development around days 12-15 of gestation precludes monitoring the effect of loss of Rb-1 function on later stages of development and on tumorigenesis in adult mice. Here we describe the developmental rescue of embryonic stem cells carrying two inactive Rb-1 alleles in chimeric mice. Rb-1- cells contributed substantially to most tissues in adult chimeras, including blood, liver and central nervous system, which were severely affected in pure Rb-1- embryos. The adult chimeric erythroid compartment appeared completely normal, but an increased number of nucleated red cells was observed during fetal liver erythropoiesis in highly chimeric embryos. No ostensive abnormalities were seen in the developing and adult CNS. However, the developing retina of chimeric Rb-1- embryos showed ectopic mitoses and substantial cell degeneration, while the contribution of Rb-1- cells to the adult retina was much reduced. Moreover, the formation of lens fibre cells was severely disturbed. No retinoblastomas developed in any of these mice. Instead, nearly all animals died of pituitary gland tumours which were exclusively derived from Rb-1- cells. Previous ArticleNext Article Volume 13Issue 181 September 1994In this issue RelatedDetailsLoading ..." @default.
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• W1477929837 date "1994-09-01" @default.
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• W1477929837 title "Developmental rescue of an embryonic-lethal mutation in the retinoblastoma gene in chimeric mice." @default.
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• W1477929837 doi "https://doi.org/10.1002/j.1460-2075.1994.tb06746.x" @default.
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