Matches in SemOpenAlex for { <https://semopenalex.org/work/W147802246> ?p ?o ?g. }
- W147802246 abstract "Acute kidney injury (AKI) occurs in up to 30% of hospitalized patients in intensive care units and independently predicts a mortality rate of approximately 40%. Most frequently, AKI results from acute tubular necrosis following hypoperfusion of the renal proximal tubular (RPT) epithelium. Regeneration following AKI is mediated by surviving RPT cells (RPTC) that dedifferentiate, proliferate, migrate, and redifferentiate to restore the damaged epithelial monolayer. Growth factors are required for all four phases of regeneration; however, their regulation of dedifferentiation/redifferentiation is not fully understood. Dedifferentiation is characterized by loss of apical–basal polarity and the brush border, formation of stress fibers, elongated cell morphology, and expression of mesenchymal proteins. Activation of several signal transduction pathways by growth factors, including transforming growth factor-β, epidermal growth factor, and fibroblast growth factor-2, mediates the phenotypic changes of dedifferentiation. The mechanism of RPTC redifferentiation is largely unexplored. The current literature suggests that several growth factors including bone morphogeneic protein-7, collagen IV, and hepatocyte growth factor mediate redifferentiation through negative regulation of signal transduction pathways that drive and maintain dedifferentiation." @default.
- W147802246 created "2016-06-24" @default.
- W147802246 creator A5004628839 @default.
- W147802246 creator A5057775605 @default.
- W147802246 date "2010-01-01" @default.
- W147802246 modified "2023-09-23" @default.
- W147802246 title "Dedifferentiation and Redifferentiation in Epithelial Repair" @default.
- W147802246 cites W1496740624 @default.
- W147802246 cites W1529505485 @default.
- W147802246 cites W1532597512 @default.
- W147802246 cites W1555070335 @default.
- W147802246 cites W1576773659 @default.
- W147802246 cites W1599507425 @default.
- W147802246 cites W1744742580 @default.
- W147802246 cites W1819766005 @default.
- W147802246 cites W1835009115 @default.
- W147802246 cites W1897523661 @default.
- W147802246 cites W1908445283 @default.
- W147802246 cites W1947484002 @default.
- W147802246 cites W1966022628 @default.
- W147802246 cites W1967695492 @default.
- W147802246 cites W1969286450 @default.
- W147802246 cites W1970228881 @default.
- W147802246 cites W1970604167 @default.
- W147802246 cites W1971175769 @default.
- W147802246 cites W1971446783 @default.
- W147802246 cites W1972881796 @default.
- W147802246 cites W1974969464 @default.
- W147802246 cites W1975933844 @default.
- W147802246 cites W1976873804 @default.
- W147802246 cites W1976884806 @default.
- W147802246 cites W1978686331 @default.
- W147802246 cites W1979597480 @default.
- W147802246 cites W1979970784 @default.
- W147802246 cites W1980325398 @default.
- W147802246 cites W1980369799 @default.
- W147802246 cites W1981184799 @default.
- W147802246 cites W1981752846 @default.
- W147802246 cites W1982342854 @default.
- W147802246 cites W1982684746 @default.
- W147802246 cites W1982706640 @default.
- W147802246 cites W1982974412 @default.
- W147802246 cites W1982999513 @default.
- W147802246 cites W1983086891 @default.
- W147802246 cites W1983460534 @default.
- W147802246 cites W1983628734 @default.
- W147802246 cites W1985301994 @default.
- W147802246 cites W1985400766 @default.
- W147802246 cites W1986811787 @default.
- W147802246 cites W1987162584 @default.
- W147802246 cites W1987452783 @default.
- W147802246 cites W1987483436 @default.
- W147802246 cites W1988002900 @default.
- W147802246 cites W198893438 @default.
- W147802246 cites W1990201193 @default.
- W147802246 cites W1990745136 @default.
- W147802246 cites W1991469068 @default.
- W147802246 cites W1992433651 @default.
- W147802246 cites W1993345123 @default.
- W147802246 cites W1993436289 @default.
- W147802246 cites W1993496373 @default.
- W147802246 cites W1993851092 @default.
- W147802246 cites W1993931106 @default.
- W147802246 cites W1994138436 @default.
- W147802246 cites W1994242450 @default.
- W147802246 cites W1994478382 @default.
- W147802246 cites W1996009633 @default.
- W147802246 cites W1996775799 @default.
- W147802246 cites W1996856448 @default.
- W147802246 cites W1999686102 @default.
- W147802246 cites W1999720300 @default.
- W147802246 cites W2002041258 @default.
- W147802246 cites W2002073980 @default.
- W147802246 cites W2002605616 @default.
- W147802246 cites W2006506188 @default.
- W147802246 cites W2007660746 @default.
- W147802246 cites W2007752398 @default.
- W147802246 cites W2008207415 @default.
- W147802246 cites W2010779418 @default.
- W147802246 cites W2012039807 @default.
- W147802246 cites W2013394636 @default.
- W147802246 cites W2017096535 @default.
- W147802246 cites W2018448237 @default.
- W147802246 cites W2019731805 @default.
- W147802246 cites W2020634703 @default.
- W147802246 cites W2021832401 @default.
- W147802246 cites W2023375965 @default.
- W147802246 cites W2025995411 @default.
- W147802246 cites W2026158123 @default.
- W147802246 cites W2026549297 @default.
- W147802246 cites W2027917795 @default.
- W147802246 cites W2028812270 @default.
- W147802246 cites W2028933700 @default.
- W147802246 cites W2029581617 @default.
- W147802246 cites W2032192204 @default.
- W147802246 cites W2032261477 @default.
- W147802246 cites W2032942532 @default.
- W147802246 cites W2034380866 @default.
- W147802246 cites W2034758456 @default.
- W147802246 cites W2035653659 @default.