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• W1478267650 abstract "Publisher Summary The chapter is for the chemist interested in tempering the motile leukocyte's response to chemo-tactic stimuli as a means to the therapeutic control of inflammatory events or to the treatment of compromised patients rendered unduly susceptible to the infectious agents because of subnormal chemotactic responses. It collected data from those reports dealing with the neutrophilic leukocyte (PMN) because of its major role in acute inflammatory processes. The aim is to identify the chemical agents that modulate induced translocation in an in vitro or in vivo setting. The chapter discusses the purported mechanism(s) of the action of the therapeutic agent. It indicates the methodology utilized in the assessment of each compound or class of compounds. The techniques utilized in the study of stimulated migration (STM) include modifications of the micro-pore filter assay (MFA), the under-agarose technique (UAT), and direct visual assessment of cell orientation toward a gradient of chemoattractant. The most widely used chemotactic factors are also discussed in the chapter. Notes given on cyclic nucleotides, their intracellular biochemical reactions coupled to the activation of the leukocyte by chemotactic factors, and the β-receptor blocking agent propranalol. Various anti-inflammatory agents and their STM suppressing properties are discussed in this chapter, along with the doses to be administered. Similarly, the chapter discusses the agents that enhance stimulated leukocyte locomotion, antibiotics, and antifungals inhibitors of arachidonate lipoxygenase. The discussions are accompanied by the figures depicting the structure for each. Several structurally dissimilar competitive inhibitors of the formylated peptide receptor have been discovered. Phenylbutazone (0.5 pM) and sulfinpyrazone (0.5 pM) inhibited chemotaxis of human PMN (MFA) toward f-Met-Leu-Phe but not C5a and antagonized f-Met-Leu-Phe induced granulocytopenia in rabbits. The chapter delves further into the receptor specific drug interactions. In recent years, specific receptors on inflammatory leukocytes have been identified and a model system within viva relevance has been reported for the formylated peptide receptor." @default.
• W1478267650 created "2016-06-24" @default.
• W1478267650 creator A5056146507 @default.
• W1478267650 creator A5078145792 @default.
• W1478267650 date "1982-01-01" @default.
• W1478267650 modified "2023-09-27" @default.
• W1478267650 title "Chapter 19. Leukocyte Motility" @default.
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• W1478267650 doi "https://doi.org/10.1016/s0065-7743(08)60501-1" @default.
• W1478267650 hasPublicationYear "1982" @default.
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