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- W1479237777 abstract "This chapter discusses tissue culture on artificial capillaries. Survival and growth of cell populations in vivo are supported by a vascular network that delivers nutrients and removes products of cellular metabolism. The capillary culture unit (CCU) consists of a network of artificial capillaries that simulates the in vivo vascular matrix. Employment of this technique permits cells to grow and to reach a density characteristic of solid tissue. In in vitro culture procedure, the CCU preserves the pericellular microenvironment and simulates the physiological conditions in which cells function in vivo. The cell population grows within the extracapillary space, and nutrients and metabolites are exchanged by diffusion from the perfusate within the capillaries. A more complex form of CCU embodies a double network of capillaries whereby differential pressure between the two capillary sets superimposes extracapillary convection on diffusion." @default.
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- W1479237777 date "1979-01-01" @default.
- W1479237777 modified "2023-09-23" @default.
- W1479237777 title "[14] Tissue Culture on Artificial Capillaries" @default.
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- W1479237777 doi "https://doi.org/10.1016/s0076-6879(79)58135-x" @default.
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