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- W1479668386 abstract "Both insulin and phorbol esters are known to inhibit the transcription of the gene for P-enolpyruvate carboxykinase (GTP) (PEPCK). The promoter-regulatory region of the PEPCK gene was analyzed for responsive sequences, using a series of chimeric genes constructed by fusing segments of the 5'-flanking region of the PEPCK gene (containing a graded set of deletions) to the structural gene for Herpes virus thymidine kinase (TK). These chimeric genes were transfected into TK-deficient rat hepatoma cells and their level of expression and regulation by insulin, phorbol ester and calcium ionophore was tested. A segment of the PEPCK promoter-regulatory region spanning 2 kb was shown to be sensitive to regulation by cAMP and glucocorticoids but not to insulin. In these same cells, insulin effectively inhibited the expression of the endogenous PEPCK gene. In a parallel set of experiments, they showed drastic alterations in the expression of the chimeric PEPCK-TK gene when cells were exposed to phorbol ester and/or calcium ionophore. These findings suggest that functional sequences required for insulin regulation of the PEPCK gene expression are 3' to the promoter-regulatory region of the gene." @default.
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- W1479668386 date "1986-05-01" @default.
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- W1479668386 title "Inhibition of p-enolpyruvate carboxykinase gene expression: role of insulin, phorbol esters and/or calcium ionophore" @default.
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