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- W1479676255 abstract "Among all the etiological agents causing diarrhea in calves, rotaviruses have a significant role and are considered as pathogens with the potential to cause huge economic losses to the livestock industry, besides causing death of millions of children in developing countries. Bovine rotavirus (BRV), a segmented ds RNA virus belonging to the family Reoviridae, is capable of cross-species transmission also. Rotavirus infection, a nonviremic disease, and causing enteritis and diarrhea in young calves, mainly gets transmitted through ingestion of feces-contaminated material. Incubation period of the disease is very short and the virus multiplies in the cytoplasm of intestinal epithelial cells (enterocytes) and gets released by cell lysis. Affected calves are presented with watery diarrhea following which fatal results are observed due to severe dehydration. The sialic acid receptors and integrins are known to act as receptors for the virus to initiate the pathogenesis, contrary to the earlier belief of direct virus entry by pinocytosis. Pathological lesions reveal mucosal congestion and the presence of catarrhal exudate in lumen of small intestine. Concurrent infection with other pathogens like Escherichia coli or bovine viral diarrhea virus (BVDV) can potentiate the disease severity. Rotavirus induces diarrhea primarily due to malabsorption based on the destruction of mature enterocytes, activation of enteric nervous system and also due to secretion of a viral enterotoxin known as non-structural protein 4 (NSP4). For diagnosis of rotaviruses, various techniques viz., electron microscopy, viral RNA-PAGE, antigen capture ELISA, dot-immunobinding, immunofluorescence test, immunoperoxidase test, passive Heme Agglutination and latex agglutination test are employed. Virus characterization is performed using Reverse Transcription-PCR (RT-PCR), Restriction Fragment Length Polymorphism (RFLP), dot blot hybridization, sequencing and microarray hybridization. For prevention and control of BRV in young calves, good management practices along with vaccinating dam with inactivated BRV vaccine a few weeks before parturition, is commonly followed. Feeding of colostrum and mucosal immunity play crucial role in providing resistance to infection in young calves. New generation vaccines like DNA vaccine, subunit vaccines, virus-like particles (VLPs) and plantbased edible vaccines are also being explored to counter this economically important disease of livestock." @default.
- W1479676255 created "2016-06-24" @default.
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- W1479676255 date "2008-01-01" @default.
- W1479676255 modified "2023-09-26" @default.
- W1479676255 title "PATHOBIOLOGY OF ROTAVIRAL DIARRHEA IN CALVES AND ITS DIAGNOSIS AND CONTROL: A REVIEW" @default.
- W1479676255 cites W122097970 @default.
- W1479676255 cites W141885545 @default.
- W1479676255 cites W1500260852 @default.
- W1479676255 cites W1516555273 @default.
- W1479676255 cites W1527217794 @default.
- W1479676255 cites W1564278654 @default.
- W1479676255 cites W1597466093 @default.
- W1479676255 cites W1628669321 @default.
- W1479676255 cites W1665750024 @default.
- W1479676255 cites W17636722 @default.
- W1479676255 cites W1777684092 @default.
- W1479676255 cites W1924842459 @default.
- W1479676255 cites W1964622720 @default.
- W1479676255 cites W1966740583 @default.
- W1479676255 cites W1977630245 @default.
- W1479676255 cites W1981904253 @default.
- W1479676255 cites W1987353274 @default.
- W1479676255 cites W1987607866 @default.
- W1479676255 cites W2008413255 @default.
- W1479676255 cites W2011054999 @default.
- W1479676255 cites W2018796588 @default.
- W1479676255 cites W2023214840 @default.
- W1479676255 cites W2025315018 @default.
- W1479676255 cites W2027708182 @default.
- W1479676255 cites W2031596285 @default.
- W1479676255 cites W2035945893 @default.
- W1479676255 cites W2036642403 @default.
- W1479676255 cites W2038972405 @default.
- W1479676255 cites W2044414307 @default.
- W1479676255 cites W2044736289 @default.
- W1479676255 cites W2048513337 @default.
- W1479676255 cites W2050064409 @default.
- W1479676255 cites W2050821158 @default.
- W1479676255 cites W2051205897 @default.
- W1479676255 cites W2056646962 @default.
- W1479676255 cites W2060324967 @default.
- W1479676255 cites W2061349189 @default.
- W1479676255 cites W2062537099 @default.
- W1479676255 cites W2067597868 @default.
- W1479676255 cites W2070987934 @default.
- W1479676255 cites W2071363916 @default.
- W1479676255 cites W2071774782 @default.
- W1479676255 cites W2076979665 @default.
- W1479676255 cites W2077990400 @default.
- W1479676255 cites W2081391723 @default.
- W1479676255 cites W2089051785 @default.
- W1479676255 cites W2097696280 @default.
- W1479676255 cites W2098232991 @default.
- W1479676255 cites W2111800130 @default.
- W1479676255 cites W2112888780 @default.
- W1479676255 cites W2114500656 @default.
- W1479676255 cites W2118783191 @default.
- W1479676255 cites W2123700924 @default.
- W1479676255 cites W2125679711 @default.
- W1479676255 cites W2130468322 @default.
- W1479676255 cites W2133845746 @default.
- W1479676255 cites W2136775584 @default.
- W1479676255 cites W2137919630 @default.
- W1479676255 cites W2142806816 @default.
- W1479676255 cites W2153759131 @default.
- W1479676255 cites W2181908191 @default.
- W1479676255 cites W2241294772 @default.
- W1479676255 cites W2246793912 @default.
- W1479676255 cites W2292068432 @default.
- W1479676255 cites W2303916465 @default.
- W1479676255 cites W2329833058 @default.
- W1479676255 cites W2394862833 @default.
- W1479676255 cites W2404478804 @default.
- W1479676255 cites W2409356655 @default.
- W1479676255 cites W2410715794 @default.
- W1479676255 cites W2412885145 @default.
- W1479676255 cites W2415237537 @default.
- W1479676255 cites W2418128190 @default.
- W1479676255 cites W2419566120 @default.
- W1479676255 cites W2422064855 @default.
- W1479676255 cites W2424011609 @default.
- W1479676255 cites W2435857290 @default.
- W1479676255 cites W2441495716 @default.
- W1479676255 cites W2461627104 @default.
- W1479676255 cites W2467961783 @default.
- W1479676255 cites W2599715710 @default.
- W1479676255 cites W89453127 @default.
- W1479676255 cites W95816450 @default.
- W1479676255 cites W1488891605 @default.
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