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• W1479713510 startingPage "133" @default.
• W1479713510 abstract "Fifteen years have gone by since the initial demonstrations of mammalian genomic imprinting (Barton et al. 1984; McGrath andSolter 1984; Surani et al. 1984), 7 years since the identification of specific imprinted genes in mice (DeChiara et al. 1991; Barlow et al. 1991; Bartolomei et al. 1991) and 6 years since the demonstration of conservation of imprinting in humans (Zhang and Tycko 1992; Giannoukakis et al. 1993; Ohlsson et al. 1993; Rainier et al. 1993; Zhang et al. 1993). During this time our understanding of the importance of this phenomenon for human diseases has advanced in some areas but remained incomplete in others. In this chapter we review data bearing on the role of genomic imprinting and imprinted genes in human cancer. We highlight the possible relationship of the regionality of imprinting and the role of imprinted genes in controlling fetal growth to the involvement of imprinting in human neoplasia. We describe data linking three imprinted genes on chromosome 11p15.5, H19, IGF2, and p57KIP2, to the pathogenesis of Wilms’ tumor (WT) and other neoplasms, as well as to the fetal overgrowth associated with the Beckwith-Wiedemann Syndrome(BWS). We discuss evidence for epimutations at the H19 locus, causing H19 silencing and biallelic activation of IGF2, as site-specific molecular lesions with a crucial permissive role in Wilms’ tumorigenesis. We also discuss the possible roles of imprinted genes in other pediatric tumors, in other proliferative and tumor syndromes, and in high grade adult malignancies. Lastly, we consider the feasibility of designing rational anticancer therapy targeting imprinted genes." @default.
• W1479713510 created "2016-06-24" @default.
• W1479713510 creator A5051475582 @default.
• W1479713510 date "1999-01-01" @default.
• W1479713510 modified "2023-10-18" @default.
• W1479713510 title "Genomic Imprinting and Cancer" @default.
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