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- W1479740369 abstract "EDITOR—Guyatt et al's proposal for analysing randomised trials1 is misguided, flies in the face of elementary statistical theory, and should be resisted. There are three obvious sources of variability in clinical trials.Firstly, pure differences occur between patients:some are more seriously ill than others. Secondly, there is variability within patients: even given the same treatment they, or their measurements, may vary from time to time. Thirdly, some patients may react more favourably to a given treatment than other patients. The parallel group trial does not and cannot distinguish between the three types of variability unless we can find meaningful ways of classifying subgroups.2The standard crossover trial will distinguish between the first type of variability and …" @default.
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- W1479740369 date "1998-08-22" @default.
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- W1479740369 title "Applying results of randomised trials to patients" @default.
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- W1479740369 doi "https://doi.org/10.1136/bmj.317.7157.537" @default.
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