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• W1479808045 abstract "Abstract The establishment of an epithelial cell line (MuMT-73) derived from spontaneous mammary tumors of BALB/cfC3H mice as a source for the continuous production of mouse mammary tumor virus (MuMTV or B particles) is described. Morphological, immunological, and biochemical techniques were used to characterize the virus. It was found that, under conditions of normal cellular growth, the cells produced only type-B particles; no concomitant synthesis of Type-C particles was detected. A unique feature of this cell line is that the cells do not produce detectable amounts of intracytoplasmic type-A particles, but many B particles were found to assemble at the cell surface with gradual development of the nucleocapsid. The kinetics of virus release into tissue culture medium after transfer of cells was studied quantitatively by particle counting and viral reverse transcriptase (RDDP) measurements. When the medium was changed every 24 hr, the cells continuously produced virus at a slow rate for up to 6 to 8 days and thereafter at an increased rate for up to 12 days. After this period, virus production gradually declined but did not decrease to the basal level. During the period of high level virus production, about 30–40% of the cells were found to produce MuMTV antigens. By estimating the total number of virus particles in the culture medium and by counting the number of antigen-positive cells, it was found that over a 20-hr period during optimum virus production a cell would release approximately 800 virus particles. Treatment of the cells with either hydrocortisone or dexamethasone resulted in an increased production of type-B particles. An additional increase in virus production was obtained when the cells were treated with insulin together with either hydrocortisone or dexamethasone." @default.
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• W1479808045 date "1977-03-01" @default.
• W1479808045 modified "2023-09-25" @default.
• W1479808045 title "Replication of mouse mammary tumor virus in tissue culture" @default.
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• W1479808045 doi "https://doi.org/10.1016/0042-6822(77)90402-0" @default.
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