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- W1479956590 abstract "The majority of intraepithelial lymphocytes (IELs) that reside within the epithelia are fully differentiated CD8 effector memory T (TEM) cells. These lymphocytes acquire their effector phenotype and functional differentiation in response to antigens in peripheral lymphoid organs.1 Consequently, one of the major achievements of the immune memory process is the gradual seeding of nonlymphoid tissues with fully differentiated CD8 TEM cells selected for the antigens present in the immediate environment. Their strategic localization suggests a critical role for these antigen-experienced cells as first-line defenders, capable of providing early immunity when invading pathogens are probably most susceptible to immune control." @default.
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- W1479956590 date "2012-09-01" @default.
- W1479956590 modified "2023-10-11" @default.
- W1479956590 title "Got IELs?" @default.
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- W1479956590 doi "https://doi.org/10.1038/mi.2012.64" @default.
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