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- W1480192010 abstract "In Escherichia coli, RNA degradation is orchestrated by the degradosome with the assistance of complementary pathways and regulatory cofactors described in this chapter. They control the stability of each transcript and regulate the expression of many genes involved in environmental adaptation. The poly(A)-dependent degradation machinery has diverse functions such as the degradation of decay intermediates generated by endoribonucleases, the control of the stability of regulatory non coding RNAs (ncRNAs) and the quality control of stable RNA. The metabolism of poly(A) and mechanism of poly(A)-assisted degradation are beginning to be understood. Regulatory factors, exemplified by RraA and RraB, control the decay rates of subsets of transcripts by binding to RNase E, in contrast to regulatory ncRNAs which, assisted by Hfq, target RNase E to specific transcripts. Destabilization is often consecutive to the translational inactivation of mRNA. However, there are examples where RNA degradation is the primary regulatory step." @default.
- W1480192010 created "2016-06-24" @default.
- W1480192010 creator A5032916783 @default.
- W1480192010 creator A5091412861 @default.
- W1480192010 date "2009-01-01" @default.
- W1480192010 modified "2023-09-25" @default.
- W1480192010 title "Chapter 4 Poly(A)‐Assisted RNA Decay and Modulators of RNA Stability" @default.
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