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• W1480222058 abstract "The Tetrahymena group I ribozyme folds into a complex three-dimensional structure for performing catalytic reactions. The catalysis depends on its catalytic core consisting of two helical domains, P4-P6 and P3-P7, connected by single stranded regions. In the folding process, most of this ribozyme folds in a hierarchical manner in which a kinetically stable intermediate determines the overall folding rate.Although the nature of this intermediate has not yet been elucidated, a mispaired P3 stem (alt-P3) appears a likely candidate. To examine the effects of the alt-P3 structure on the kinetic and thermodynamic properties of the active structure of the ribozyme or its P3-P7 domain formation, we prepared and analysed variant ribozymes in which relative stabilities of the original P3 and alt-P3 structure were altered systematically.The results indicate that the alt-P3 structure is not the major rate-limiting factor in the folding process." @default.
• W1480222058 created "2016-06-24" @default.
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• W1480222058 date "2002-08-01" @default.
• W1480222058 modified "2023-09-23" @default.
• W1480222058 title "Mispaired P3 region in the hierarchical folding pathway of the Tetrahymena ribozyme" @default.
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• W1480222058 doi "https://doi.org/10.1046/j.1365-2443.2002.00567.x" @default.
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