FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1480285457> ?p ?o ?g. }

• W1480285457 endingPage "500" @default.
• W1480285457 startingPage "493" @default.
• W1480285457 abstract "Cisplatin-induced ototoxicity limits its wide application in the treatment of cancer. A number of pro-inflammatory factors have been shown to be involved in cisplatin-induced ototoxicity. Trichostatin A (TSA) is an anti-inflammatory agent that has been shown to exert protective effects against cisplatin-induced ototoxicity. In the present study, we hypothesized that TSA may protect cochlear hair cells from cisplatin-induced damage by regulating the interleukin (IL)-4/signal transducer and activator of transcription (STAT)6 signaling pathway. Wistar rat cochlear explants were cultured in DMEM. The differentially expressed genes of the basilar membrane were identified by microarray analysis of global expression profiles. Hair cells were stained with rhodamine phalloidin and observed under a scanning electron microscope to evaluate the protective effects of TSA against cisplatin-induced cochlear hair cell damage. The levels of cytokines in the supernatant of the cultured basilar membranes was measured using ELISA. STAT6 and phosphorylated (p-)STAT6 expression was measured by western blot analysis. Morphological observation revealed that cisplatin induced the disarrangement of the cochlear hair cells, as well as the fusion and detachment of the cilia, while these aberrant alterations were inhibited by TSA, suggesting that TSA exerts a protective effect against cisplatin-induced damage to hair cells. Furthermore, the increase in the expression of STAT6 and p-STAT6 induced by cisplatin was reversed by treatment with TSA, accompanied by the decreased expression of IL-1β, IL-4 and IL-6. Therefore, our data demonstrate that TSA reduces cisplatin-induced ototoxicity by inhibiting pro-inflammatory factor-mediated STAT6 signaling. Thus, TSA may be used to prevent the side-effects associated with the use of cisplatin in cancer treatment." @default.
• W1480285457 created "2016-06-24" @default.
• W1480285457 creator A5021110763 @default.
• W1480285457 creator A5023080294 @default.
• W1480285457 creator A5050344464 @default.
• W1480285457 creator A5052004775 @default.
• W1480285457 creator A5065418722 @default.
• W1480285457 creator A5071844040 @default.
• W1480285457 date "2015-06-16" @default.
• W1480285457 modified "2023-09-27" @default.
• W1480285457 title "Trichostatin A reduces cisplatin-induced ototoxicity through the STAT6 signaling pathway" @default.
• W1480285457 cites W1963667480 @default.
• W1480285457 cites W1964570018 @default.
• W1480285457 cites W1968314562 @default.
• W1480285457 cites W1981528128 @default.
• W1480285457 cites W1985158343 @default.
• W1480285457 cites W1987604182 @default.
• W1480285457 cites W1990721760 @default.
• W1480285457 cites W1996442906 @default.
• W1480285457 cites W1999218213 @default.
• W1480285457 cites W2000117948 @default.
• W1480285457 cites W2000697304 @default.
• W1480285457 cites W2001900968 @default.
• W1480285457 cites W2014859323 @default.
• W1480285457 cites W2019801716 @default.
• W1480285457 cites W2021408555 @default.
• W1480285457 cites W2023099360 @default.
• W1480285457 cites W2024783145 @default.
• W1480285457 cites W2033281822 @default.
• W1480285457 cites W2035737985 @default.
• W1480285457 cites W2038528969 @default.
• W1480285457 cites W2044397540 @default.
• W1480285457 cites W2046207757 @default.
• W1480285457 cites W2046983501 @default.
• W1480285457 cites W2066372854 @default.
• W1480285457 cites W2070150128 @default.
• W1480285457 cites W2075490622 @default.
• W1480285457 cites W2082313150 @default.
• W1480285457 cites W2082685967 @default.
• W1480285457 cites W2090539461 @default.
• W1480285457 cites W2091665451 @default.
• W1480285457 cites W2116116157 @default.
• W1480285457 cites W2126158121 @default.
• W1480285457 cites W2130518301 @default.
• W1480285457 cites W2152702691 @default.
• W1480285457 cites W2153268309 @default.
• W1480285457 cites W2159217195 @default.
• W1480285457 doi "https://doi.org/10.3892/ijmm.2015.2249" @default.
• W1480285457 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26080623" @default.
• W1480285457 hasPublicationYear "2015" @default.
• W1480285457 type Work @default.
• W1480285457 sameAs 1480285457 @default.
• W1480285457 citedByCount "7" @default.
• W1480285457 countsByYear W14802854572017 @default.
• W1480285457 countsByYear W14802854572018 @default.
• W1480285457 countsByYear W14802854572020 @default.
• W1480285457 crossrefType "journal-article" @default.
• W1480285457 hasAuthorship W1480285457A5021110763 @default.
• W1480285457 hasAuthorship W1480285457A5023080294 @default.
• W1480285457 hasAuthorship W1480285457A5050344464 @default.
• W1480285457 hasAuthorship W1480285457A5052004775 @default.
• W1480285457 hasAuthorship W1480285457A5065418722 @default.
• W1480285457 hasAuthorship W1480285457A5071844040 @default.
• W1480285457 hasBestOaLocation W14802854571 @default.
• W1480285457 hasConcept C104317684 @default.
• W1480285457 hasConcept C153911025 @default.
• W1480285457 hasConcept C185592680 @default.
• W1480285457 hasConcept C2776694085 @default.
• W1480285457 hasConcept C2777865847 @default.
• W1480285457 hasConcept C2778239845 @default.
• W1480285457 hasConcept C2778305200 @default.
• W1480285457 hasConcept C2778534666 @default.
• W1480285457 hasConcept C502942594 @default.
• W1480285457 hasConcept C54355233 @default.
• W1480285457 hasConcept C55493867 @default.
• W1480285457 hasConcept C62478195 @default.
• W1480285457 hasConcept C64927066 @default.
• W1480285457 hasConcept C86803240 @default.
• W1480285457 hasConcept C95444343 @default.
• W1480285457 hasConceptScore W1480285457C104317684 @default.
• W1480285457 hasConceptScore W1480285457C153911025 @default.
• W1480285457 hasConceptScore W1480285457C185592680 @default.
• W1480285457 hasConceptScore W1480285457C2776694085 @default.
• W1480285457 hasConceptScore W1480285457C2777865847 @default.
• W1480285457 hasConceptScore W1480285457C2778239845 @default.
• W1480285457 hasConceptScore W1480285457C2778305200 @default.
• W1480285457 hasConceptScore W1480285457C2778534666 @default.
• W1480285457 hasConceptScore W1480285457C502942594 @default.
• W1480285457 hasConceptScore W1480285457C54355233 @default.
• W1480285457 hasConceptScore W1480285457C55493867 @default.
• W1480285457 hasConceptScore W1480285457C62478195 @default.
• W1480285457 hasConceptScore W1480285457C64927066 @default.
• W1480285457 hasConceptScore W1480285457C86803240 @default.
• W1480285457 hasConceptScore W1480285457C95444343 @default.
• W1480285457 hasIssue "2" @default.
• W1480285457 hasLocation W14802854571 @default.
• W1480285457 hasLocation W14802854572 @default.
• W1480285457 hasOpenAccess W1480285457 @default.

• next