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- W1480340736 abstract "Disorder of interventricular interaction take place in patients with chronic obstructive pulmonary disease (COPD). Aim of the study - assessment of left ventricular (LV) dysfunction, systemic inflammation and endothelial function in COPD patients with chronic cor pulmonale.Materials. Endothelium-dependent vasodilatation of brachial artery (EDVD), echo data of left and right heart, the concentration of pro-inflammatory and anti-inflammatory cytokines and circulating immune complexes (CIC) in plasma were studied in 92 patients with 2 and 3 stages COPD.Results. Our results showed the reduction of left ventricular contractile activity, more in stage 3 COPD patients. Degradation EDVD was found in 72% of patients with 2 stage and 91% in 3 stages COPD. In the development of LV failure involved a disorder of interventricular interaction. In COPD patients at an early stage of the disease were detected an imbalance of pro- and anti- inflammatory cytokines, increasing the concentration of CIC. Significant correlations (p<0.05) were found in stage 3 COPD patients: between systolic pulmonary artery pressure (SPAP) and concentration of the CIC (r=0.39), SPAP and level of IL-1β (r=0.43), and IL-8 (r=-0.64), and LV ejection fraction (r=-0.48). In stage 2 COPD patients significant correlations between SPAP and CIC (r=0.33), and IL-8 (r=-0.36) were found.Thus, developing systemic inflammation and endothelial dysfunction contribute not only to the formation of pulmonary hypertension and chronic cor pulmonale, but also the development of left ventricular failure. Joining left ventricular failure in patients with COPD increases the degree of hemodynamic disorders, reduces the quality and duration of life." @default.
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- W1480340736 date "2014-09-01" @default.
- W1480340736 modified "2023-09-24" @default.
- W1480340736 title "COPD: Left ventricular dysfunction, systemic inflammation and endothelial dysfunction" @default.
- W1480340736 hasPublicationYear "2014" @default.
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