Matches in SemOpenAlex for { <https://semopenalex.org/work/W1480361432> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W1480361432 endingPage "139" @default.
- W1480361432 startingPage "132" @default.
- W1480361432 abstract "Mononuclear cells (MC) from many individuals exposed to human immunodeficiency virus (HIV) exhibit a reduced proliferative response to a suboptimal concentration of phytohemagglutinin (PHA). However, the relative contributions of the 2 major T-cell subsets, namely CD4 and CD8 lymphocytes, to this reduced response remain unclear. Based on reports that interleukin 2 receptor (IL2R) expression correlates well with proliferative responses in HIV infection, we used dual-color cytofluorometry to measure IL2R expression by CD4 and CD8 cells following PHA activation of MC from HIV-seropositive blood donors. For data analysis, this study group was divided into two subgroups on the basis of DNA synthesis responses (seropositive with normal DNA synthesis, designated sero _ NML, or seropositive with decreased DNA synthesis, designated sero + LOW). When compared to the seronegative control and sero + NML groups, the sero + LOW group exhibited significant reductions in the percentage of MC expressing IL2R, the proportion of CD4 cells expressing IL2R, and the proportion of CD8 cells expressing IL2R. In contrast, these parameters were unchanged in the sero + NML group compared to the control group. These findings show that reduced PHA-induced proliferative responses by MC from HIV-infected persons are associated with decreased IL2R expression by both CD4 and CD8 lymphocyte subsets." @default.
- W1480361432 created "2016-06-24" @default.
- W1480361432 creator A5030464858 @default.
- W1480361432 creator A5062218754 @default.
- W1480361432 date "1988-08-01" @default.
- W1480361432 modified "2023-09-26" @default.
- W1480361432 title "In vitro activation of T lymphocytes from HIV-seropositive blood donors" @default.
- W1480361432 cites W1491217262 @default.
- W1480361432 cites W1513452110 @default.
- W1480361432 cites W1966085066 @default.
- W1480361432 cites W1968865286 @default.
- W1480361432 cites W1976745468 @default.
- W1480361432 cites W1991670386 @default.
- W1480361432 cites W1996249519 @default.
- W1480361432 cites W1996901403 @default.
- W1480361432 cites W2000485108 @default.
- W1480361432 cites W2031546643 @default.
- W1480361432 cites W2051670536 @default.
- W1480361432 cites W2066121768 @default.
- W1480361432 cites W2072090735 @default.
- W1480361432 cites W2075974793 @default.
- W1480361432 cites W2079197435 @default.
- W1480361432 cites W2105875086 @default.
- W1480361432 cites W2137267461 @default.
- W1480361432 cites W2335496717 @default.
- W1480361432 doi "https://doi.org/10.1016/0090-1229(88)90077-3" @default.
- W1480361432 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2968871" @default.
- W1480361432 hasPublicationYear "1988" @default.
- W1480361432 type Work @default.
- W1480361432 sameAs 1480361432 @default.
- W1480361432 citedByCount "11" @default.
- W1480361432 crossrefType "journal-article" @default.
- W1480361432 hasAuthorship W1480361432A5030464858 @default.
- W1480361432 hasAuthorship W1480361432A5062218754 @default.
- W1480361432 hasConcept C137061746 @default.
- W1480361432 hasConcept C153911025 @default.
- W1480361432 hasConcept C159047783 @default.
- W1480361432 hasConcept C167672396 @default.
- W1480361432 hasConcept C202751555 @default.
- W1480361432 hasConcept C203014093 @default.
- W1480361432 hasConcept C2522874641 @default.
- W1480361432 hasConcept C2777761686 @default.
- W1480361432 hasConcept C2992881475 @default.
- W1480361432 hasConcept C55493867 @default.
- W1480361432 hasConcept C86803240 @default.
- W1480361432 hasConcept C8891405 @default.
- W1480361432 hasConceptScore W1480361432C137061746 @default.
- W1480361432 hasConceptScore W1480361432C153911025 @default.
- W1480361432 hasConceptScore W1480361432C159047783 @default.
- W1480361432 hasConceptScore W1480361432C167672396 @default.
- W1480361432 hasConceptScore W1480361432C202751555 @default.
- W1480361432 hasConceptScore W1480361432C203014093 @default.
- W1480361432 hasConceptScore W1480361432C2522874641 @default.
- W1480361432 hasConceptScore W1480361432C2777761686 @default.
- W1480361432 hasConceptScore W1480361432C2992881475 @default.
- W1480361432 hasConceptScore W1480361432C55493867 @default.
- W1480361432 hasConceptScore W1480361432C86803240 @default.
- W1480361432 hasConceptScore W1480361432C8891405 @default.
- W1480361432 hasIssue "2" @default.
- W1480361432 hasLocation W14803614321 @default.
- W1480361432 hasLocation W14803614322 @default.
- W1480361432 hasOpenAccess W1480361432 @default.
- W1480361432 hasPrimaryLocation W14803614321 @default.
- W1480361432 hasRelatedWork W1506984959 @default.
- W1480361432 hasRelatedWork W1967623526 @default.
- W1480361432 hasRelatedWork W2001310869 @default.
- W1480361432 hasRelatedWork W2056385328 @default.
- W1480361432 hasRelatedWork W2090531156 @default.
- W1480361432 hasRelatedWork W2361697202 @default.
- W1480361432 hasRelatedWork W2376822718 @default.
- W1480361432 hasRelatedWork W243876670 @default.
- W1480361432 hasRelatedWork W4220809286 @default.
- W1480361432 hasRelatedWork W91868852 @default.
- W1480361432 hasVolume "48" @default.
- W1480361432 isParatext "false" @default.
- W1480361432 isRetracted "false" @default.
- W1480361432 magId "1480361432" @default.
- W1480361432 workType "article" @default.