Matches in SemOpenAlex for { <https://semopenalex.org/work/W1480454985> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W1480454985 endingPage "2125" @default.
- W1480454985 startingPage "2118" @default.
- W1480454985 abstract "Abstract Prostaglandin E2 (PGE2) synthesis by macrophages was measured in normal and tumor-bearing mice. Splenic macrophages from C57BL mice bearing a transplantable, nonmetastasizing methylcholanthrene-induced fibrosarcoma produced significantly more PGE than cells from normal nontumor-bearing littermates. Augmented PG synthesis was found basally and after nonspecific stimulation of macrophages with endotoxin (LPS) and concanavalin A (Con A) as measured by radioimmunoassay. Resident peritoneal macrophages showed similar differences in radioimmunoassayable PGE levels. The conversion to prostaglandins of radiolabeled arachidonic acid previously incorporated into membrane phospholipids was followed over time. Macrophages from both normal and tumor-bearing animals incorporated equivalent amounts of tritiated arachidonic acid, showed similar distribution of label in phospholipid pools, and released equivalent amounts of labeled Arachidonic Acid and phospholipid. However, at both 3 and 18 hr of incubation, unstimulated macrophages from tumor-bearing animals released significantly more PGE2 and 6-keto PGF1α (the metabolite of prostacyclin) compared to macrophages from normal animals. Nonspecific stimuli (Con A and zymosan) greatly augmented PG production in both animal groups, with tumor-bearers greater than with normals. LPS caused little augmentation in basal PG secretion at 3 hr, but it greatly increased synthesis measured 18 hr later. In similar experiments, Moloney sarcoma virus (MSV) could be shown to augment PG synthesis in BALB/c mice bearing a transplantable MSV-transformed tumor line, but not in normal animals. No significant difference was noted in adherence, morphology, phagocytosis, or enzymatic activity when the resident macrophages from normal and tumor-bearing animals were compared, suggesting that they were at the same relative state of activation but differed in their capacity to synthesize prostaglandins." @default.
- W1480454985 created "2016-06-24" @default.
- W1480454985 creator A5000560911 @default.
- W1480454985 creator A5063108298 @default.
- W1480454985 date "1979-11-01" @default.
- W1480454985 modified "2023-10-06" @default.
- W1480454985 title "Increased Prostaglandin Synthesis by Macrophages from Tumor-Bearing Mice" @default.
- W1480454985 doi "https://doi.org/10.4049/jimmunol.123.5.2118" @default.
- W1480454985 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/489975" @default.
- W1480454985 hasPublicationYear "1979" @default.
- W1480454985 type Work @default.
- W1480454985 sameAs 1480454985 @default.
- W1480454985 citedByCount "71" @default.
- W1480454985 crossrefType "journal-article" @default.
- W1480454985 hasAuthorship W1480454985A5000560911 @default.
- W1480454985 hasAuthorship W1480454985A5063108298 @default.
- W1480454985 hasBestOaLocation W14804549851 @default.
- W1480454985 hasConcept C126322002 @default.
- W1480454985 hasConcept C134018914 @default.
- W1480454985 hasConcept C160448771 @default.
- W1480454985 hasConcept C176685330 @default.
- W1480454985 hasConcept C181199279 @default.
- W1480454985 hasConcept C185592680 @default.
- W1480454985 hasConcept C19869320 @default.
- W1480454985 hasConcept C202751555 @default.
- W1480454985 hasConcept C203014093 @default.
- W1480454985 hasConcept C24998067 @default.
- W1480454985 hasConcept C2776495794 @default.
- W1480454985 hasConcept C2777198256 @default.
- W1480454985 hasConcept C2777956040 @default.
- W1480454985 hasConcept C2778078955 @default.
- W1480454985 hasConcept C2778870864 @default.
- W1480454985 hasConcept C2778918659 @default.
- W1480454985 hasConcept C2779244956 @default.
- W1480454985 hasConcept C2780664492 @default.
- W1480454985 hasConcept C41625074 @default.
- W1480454985 hasConcept C54355233 @default.
- W1480454985 hasConcept C55493867 @default.
- W1480454985 hasConcept C71924100 @default.
- W1480454985 hasConcept C86803240 @default.
- W1480454985 hasConceptScore W1480454985C126322002 @default.
- W1480454985 hasConceptScore W1480454985C134018914 @default.
- W1480454985 hasConceptScore W1480454985C160448771 @default.
- W1480454985 hasConceptScore W1480454985C176685330 @default.
- W1480454985 hasConceptScore W1480454985C181199279 @default.
- W1480454985 hasConceptScore W1480454985C185592680 @default.
- W1480454985 hasConceptScore W1480454985C19869320 @default.
- W1480454985 hasConceptScore W1480454985C202751555 @default.
- W1480454985 hasConceptScore W1480454985C203014093 @default.
- W1480454985 hasConceptScore W1480454985C24998067 @default.
- W1480454985 hasConceptScore W1480454985C2776495794 @default.
- W1480454985 hasConceptScore W1480454985C2777198256 @default.
- W1480454985 hasConceptScore W1480454985C2777956040 @default.
- W1480454985 hasConceptScore W1480454985C2778078955 @default.
- W1480454985 hasConceptScore W1480454985C2778870864 @default.
- W1480454985 hasConceptScore W1480454985C2778918659 @default.
- W1480454985 hasConceptScore W1480454985C2779244956 @default.
- W1480454985 hasConceptScore W1480454985C2780664492 @default.
- W1480454985 hasConceptScore W1480454985C41625074 @default.
- W1480454985 hasConceptScore W1480454985C54355233 @default.
- W1480454985 hasConceptScore W1480454985C55493867 @default.
- W1480454985 hasConceptScore W1480454985C71924100 @default.
- W1480454985 hasConceptScore W1480454985C86803240 @default.
- W1480454985 hasIssue "5" @default.
- W1480454985 hasLocation W14804549851 @default.
- W1480454985 hasLocation W14804549852 @default.
- W1480454985 hasOpenAccess W1480454985 @default.
- W1480454985 hasPrimaryLocation W14804549851 @default.
- W1480454985 hasRelatedWork W1964058457 @default.
- W1480454985 hasRelatedWork W2016034363 @default.
- W1480454985 hasRelatedWork W2018834553 @default.
- W1480454985 hasRelatedWork W2024092574 @default.
- W1480454985 hasRelatedWork W2048466985 @default.
- W1480454985 hasRelatedWork W2056100207 @default.
- W1480454985 hasRelatedWork W2073581677 @default.
- W1480454985 hasRelatedWork W2089925568 @default.
- W1480454985 hasRelatedWork W2331274836 @default.
- W1480454985 hasRelatedWork W99532986 @default.
- W1480454985 hasVolume "123" @default.
- W1480454985 isParatext "false" @default.
- W1480454985 isRetracted "false" @default.
- W1480454985 magId "1480454985" @default.
- W1480454985 workType "article" @default.