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• W1480455094 endingPage "7555" @default.
• W1480455094 startingPage "7555" @default.
• W1480455094 abstract "To examine the effect of pseudolaric acid B on the growth of human gastric cancer cell line, AGS, and its possible mechanism of action.Growth inhibition by pseudolaric acid B was analyzed using MTT assay. Apoptotic cells were detected using Hoechst 33258 staining, and confirmed by DNA fragmentation analysis. Western blot was used to detect the expression of apoptosis-regulated gene Bcl-2, caspase 3, and cleavage of poly (ADP-ribose) polymerase-1 (PARP-1).Pseudolaric acid B inhibited the growth of AGS cells in a time- and dose-dependent manner by arresting the cells at G(2)/M phase, which was accompanied with a decrease in the levels of cdc2. AGS cells treated with pseudolaric acid B showed typical characteristics of apoptosis including chromatin condensation and DNA fragmentation. Moreover, treatment of AGS cells with pseudolaric acid B was also associated with decreased levels of the anti-apoptotic protein Bcl-2, activation of caspase-3, and proteolytic cleavage of PARP-1.Pseudolaric acid B can dramatically suppress the AGS cell growth by inducing apoptosis after G(2)/M phase arrest. These findings are consistent with the possibility that G(2)/M phase arrest is mediated by the down-regulation of cdc2 levels. The data also suggest that pseudolaric acid B can trigger apoptosis by decreasing Bcl-2 levels and activating caspase-3 protease." @default.
• W1480455094 created "2016-06-24" @default.
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• W1480455094 date "2005-01-01" @default.
• W1480455094 modified "2023-10-09" @default.
• W1480455094 title "Effect of pseudolaric acid B on gastric cancer cells: Inhibition of proliferation and induction of apoptosis" @default.
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• W1480455094 doi "https://doi.org/10.3748/wjg.v11.i48.7555" @default.
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