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- W1480464584 abstract "Silent information regulation factor 2 related enzyme Ⅰ (SIRT1) is a coenzyme NAD(superscript +) dependent deacetylase, not only related to aging, dying and DNA repairing, but also correlative with cellular metabolic transformation in different nutrition stress states.SIRT1 and AMPK are energy receptors in cells, regulating the activity of PGC-1α by means of phosphorylation and deacetylation. The regulation of the activity of the AMPK/SIRT1/PGC-1α axis directly affects the expression of its downstream genes related, being closely related to the occurrence and development of insulin resistance." @default.
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- W1480464584 date "2010-11-28" @default.
- W1480464584 modified "2023-10-18" @default.
- W1480464584 title "运动对胰岛素抵抗骨骼肌AMPK/SIRT1/PGC-1α轴影响的研究述评" @default.
- W1480464584 hasPublicationYear "2010" @default.
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