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• W1480478804 abstract "A stimulation of gluconeogenesis by excessive intake of retinol is suggested on the basis of enhanced incorporation of [2-14C]glycine into liver glycogen in rats fed excess retinol. Among the key gluconeogenic enzymes studied, activities of hepatic PEP-carboxykinase, fructose-1,6-bisphosphatase, glucose-6-phosphatase, and alanine aminotransferase were markedly increased, whereas that of pyruvate carboxylase remained unaltered. However, feeding of retinol to bilaterally adrenalectomized rats or rats treated with actinomycin D failed to cause significant increase in the activities of these enzymes. It is concluded that (i) gluconeogenesis is stimulated by excess retinol due to, perhaps, increased activities of key gluconeogenic enzymes, and (ii) adrenals are directly or indirectly involved in the retinol-mediated increase in the activities of the gluconeogenic enzymes. Also, data are presented that indicate a requirement for protein synthesis for the expression of retinol-mediated alterations in the activities of gluconeogenic enzymes." @default.
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• W1480478804 date "1976-03-01" @default.
• W1480478804 modified "2023-10-18" @default.
• W1480478804 title "Early effects of excessive retinol intake on gluconeogenesis" @default.
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• W1480478804 doi "https://doi.org/10.1016/0003-9861(76)90237-x" @default.
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