Matches in SemOpenAlex for { <https://semopenalex.org/work/W1480508732> ?p ?o ?g. }
- W1480508732 abstract "For T cell activation, three signals have to be provided from the antigen presenting cell; Signal 1 (antigen recognition), signal 2 (co-stimulation) and signal 3 (cytokine priming). Blocking negative co-stimulation during antigen presentation to T cells is becoming a promising therapeutic strategy to enhance cancer immunotherapy. Here we will focus on interference with PD-1/PD-L1 negative co-stimulation during antigen presentation to T cells as a therapeutic approach. We will discuss the potential mechanisms and the therapeutic consequences by which interference/inhibition with this interaction results in anti-tumour immunity. Particularly, we will comment on whether blocking negative co-stimulation provides differentiation signals to T cells undergoing antigen presentation. A major dogma in immunology states that T cell differentiation signals are given by cytokines and chemokines (signal 3) rather than co-stimulation (signal 2). We will discuss whether this is the case when blocking PD-L1/PD-1 negative co-stimulation." @default.
- W1480508732 created "2016-06-24" @default.
- W1480508732 creator A5009369215 @default.
- W1480508732 creator A5028109176 @default.
- W1480508732 creator A5048780479 @default.
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- W1480508732 creator A5066282880 @default.
- W1480508732 creator A5079534384 @default.
- W1480508732 creator A5091638762 @default.
- W1480508732 date "2013-01-01" @default.
- W1480508732 modified "2023-09-27" @default.
- W1480508732 title "Signaling Mechanisms that Balance Anti-viral, Auto-reactive, and Antitumor Potential of Low Affinity T Cells" @default.
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- W1480508732 doi "https://doi.org/10.4172/2155-9899.s12-006" @default.
- W1480508732 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3605779" @default.
- W1480508732 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23525238" @default.
- W1480508732 hasPublicationYear "2013" @default.