FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1480521952> ?p ?o ?g. }

• W1480521952 endingPage "98" @default.
• W1480521952 startingPage "79" @default.
• W1480521952 abstract "Progestins have diverse effects on cell proliferation in progestin target tissues which are developmentally regulated as well as being species- and cell type-specific. Both stimulatory and inhibitory effects are well documented but it is still unclear whether the stimulatory effects are sustained, i.e., whether they result in continued rounds of cell replication or result in transient effects on a given cell population, inducing a single round of replication before cells undergo terminal differentiation. The inhibitory effects have been more clearly defined, particularly for endometrial epithelium in vivo and for both endometrial and breast carcinoma cells in vitro. Progestin-induced inhibition of cell proliferation results from a block in cell cycle progression in early G1 phase immediately after mitosis indicating that progestins inhibit the production and/or functions of genes critical to progression through early G1 phase. These genes have not been identified but candidates include the proto-oncogene c-myc and the G1 cyclins, particularly cyclin D1 and its kinase partners. Recent studies employing human mammary carcinoma cells as models have documented a progestin-induced stimulation of cell cycle progression in G1 phase. This effect appears to be confined to cells that are already in G1 phase and leads to accelerated progression through this phase of the cell cycle. Since other phases appear unaffected, the resultant effect is a significantly reduced cell generation time, i.e., an increased rate of cell proliferation. Whether or not this is a good model for the stimulatory effects of progestins in vivo remains to be established. Studies of changes in gene expression accompanying increased G1 transit have demonstrated that this effect is preceded by induction of c-myc and cyclin D1. Since delayed administration of a progestin antagonist inhibited cell cycle progression and cyclin D1 induction and the effects of progestins were mimicked by inducible expression of a transfected cyclin D1 construct, there is strong evidence that transcriptional activation of cyclin D1 is causal for progestin stimulation of cell proliferation. These data, generated from well-characterized experimental models in vitro, have facilitated progress in our understanding of mechanisms of progestin action. The hypotheses developed from these systems urgently need to be validated in a broader spectrum of progestin target tissues including female reproductive organs in vivo. Such data are essential to an understanding of the further physiology of progestin action and the optimal use of progestins in the management of human disease." @default.
• W1480521952 created "2016-06-24" @default.
• W1480521952 creator A5027248689 @default.
• W1480521952 creator A5067798845 @default.
• W1480521952 date "1996-01-01" @default.
• W1480521952 modified "2023-09-24" @default.
• W1480521952 title "Chapter 4 Progestin regulation of cellular proliferation" @default.
• W1480521952 cites W1981288290 @default.
• W1480521952 cites W2012741600 @default.
• W1480521952 cites W2056357500 @default.
• W1480521952 cites W2080052483 @default.
• W1480521952 cites W2095565562 @default.
• W1480521952 cites W2109583847 @default.
• W1480521952 cites W2121625670 @default.
• W1480521952 cites W2149308203 @default.
• W1480521952 cites W2401522950 @default.
• W1480521952 cites W2890404096 @default.
• W1480521952 cites W4241665805 @default.
• W1480521952 cites W4244525013 @default.
• W1480521952 cites W4252470656 @default.
• W1480521952 cites W4253789129 @default.
• W1480521952 doi "https://doi.org/10.1016/s1569-254x(96)80006-9" @default.
• W1480521952 hasPublicationYear "1996" @default.
• W1480521952 type Work @default.
• W1480521952 sameAs 1480521952 @default.
• W1480521952 citedByCount "2" @default.
• W1480521952 countsByYear W14805219522021 @default.
• W1480521952 countsByYear W14805219522022 @default.
• W1480521952 crossrefType "book-chapter" @default.
• W1480521952 hasAuthorship W1480521952A5027248689 @default.
• W1480521952 hasAuthorship W1480521952A5067798845 @default.
• W1480521952 hasConcept C120089663 @default.
• W1480521952 hasConcept C126322002 @default.
• W1480521952 hasConcept C134018914 @default.
• W1480521952 hasConcept C1491633281 @default.
• W1480521952 hasConcept C199835354 @default.
• W1480521952 hasConcept C2908647359 @default.
• W1480521952 hasConcept C29537977 @default.
• W1480521952 hasConcept C502942594 @default.
• W1480521952 hasConcept C54355233 @default.
• W1480521952 hasConcept C62112901 @default.
• W1480521952 hasConcept C71924100 @default.
• W1480521952 hasConcept C86803240 @default.
• W1480521952 hasConcept C93304396 @default.
• W1480521952 hasConcept C95444343 @default.
• W1480521952 hasConcept C99454951 @default.
• W1480521952 hasConceptScore W1480521952C120089663 @default.
• W1480521952 hasConceptScore W1480521952C126322002 @default.
• W1480521952 hasConceptScore W1480521952C134018914 @default.
• W1480521952 hasConceptScore W1480521952C1491633281 @default.
• W1480521952 hasConceptScore W1480521952C199835354 @default.
• W1480521952 hasConceptScore W1480521952C2908647359 @default.
• W1480521952 hasConceptScore W1480521952C29537977 @default.
• W1480521952 hasConceptScore W1480521952C502942594 @default.
• W1480521952 hasConceptScore W1480521952C54355233 @default.
• W1480521952 hasConceptScore W1480521952C62112901 @default.
• W1480521952 hasConceptScore W1480521952C71924100 @default.
• W1480521952 hasConceptScore W1480521952C86803240 @default.
• W1480521952 hasConceptScore W1480521952C93304396 @default.
• W1480521952 hasConceptScore W1480521952C95444343 @default.
• W1480521952 hasConceptScore W1480521952C99454951 @default.
• W1480521952 hasLocation W14805219521 @default.
• W1480521952 hasOpenAccess W1480521952 @default.
• W1480521952 hasPrimaryLocation W14805219521 @default.
• W1480521952 hasRelatedWork W1977517636 @default.
• W1480521952 hasRelatedWork W1993083676 @default.
• W1480521952 hasRelatedWork W2054608659 @default.
• W1480521952 hasRelatedWork W2059386627 @default.
• W1480521952 hasRelatedWork W2762525387 @default.
• W1480521952 hasRelatedWork W2885613938 @default.
• W1480521952 hasRelatedWork W2889145277 @default.
• W1480521952 hasRelatedWork W3106032671 @default.
• W1480521952 hasRelatedWork W3209090203 @default.
• W1480521952 hasRelatedWork W4281769617 @default.
• W1480521952 isParatext "false" @default.
• W1480521952 isRetracted "false" @default.
• W1480521952 magId "1480521952" @default.
• W1480521952 workType "book-chapter" @default.