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• W1480612043 abstract "RESUMO. Nas ultimas decadas a propriedade inibitoria dos oleos essenciais vegetais frente a Candida spp. tem sido estudada, estando a do oregano entre eles. Todavia, sao escassos os trabalhos sobre a toxicidade do referido oleo. Assim, o objetivo do presente estudo foi avaliar a toxicidade do oleo essencial do Origanum vulgare administrado em ratas Wistar, adultas. Quatro grupos experimentais foram constituidos, grupo I (oleo por via oral, n = 10); grupo II (controle oral, n = 5), grupo III, (oleo por via intra-vaginal, n = 10) e grupo IV (controle intra-vaginal, n = 5). O tratamento diario foi realizado por 30 dias. Utilizou-se emulsao a 3% vol/vol do oleo essencial de O. vulgare que apresentava os seguintes constituintes: γ-terpineno (4,86 %), 4-terpineol (47,95 %), α-terpineol (7,56 %), timol (8,42 %) e carvacrol (9,43 %). Ao final do tratamento, os animais foram sacrificados, sendo realizadas necropsias. Os resultados nao evidenciaram qualquer alteracao macroscopica nos tecidos do trato reprodutivo e digestorio, assim como em figado, baco e rins. Nas avaliacoes clinicas, hematologicas e histopatologicas nao foram observadas alteracoes. De acordo com os resultados obtidos, conclui-se que o oleo essencial do O. vulgare nao causa alteracoes toxicologicas relevantes, quando administrado a 3% por via oral e intra-vaginal em ratas Wistar, por 30 dias. Outros estudos sao necessarios, incluindo um periodo maior de administracao e, utilizando oleos com diferentes proporcoes de terpenos, alem da avaliacao da toxicidade reprodutiva. SUMMARY. “Pre-clinic toxicity of the repeate-dose of Origanum vulgare L. (Origanum) essential Oil in Wistar Rats”. In recent decades the inhibitory property of the essential oils against Candida spp. has been studied, and antimicrobial activities of origanum has been evaluated. However, the papers evaluating the toxicity of this oil are scarce.The objective of this work was to evaluate the toxicity of the Origanum vulgare essential oil administered orally and intravaginal in adult female Wistar rats. This study was accomplished with 4 groups of female rats, group I (oil administration orally, n = 10); group II (control orally, n = 5), group III, (oil administration intravaginal, n = 10) and group IV (control intravaginal, n = 5). The treatment for 30 days, everyday. The essential oil was used 3 % (v/v) in emulsion, and concentration of main compounds were: γ-terpinene (4.86 %), 4-terpineol (47.95 %), α-terpineol (7.56 %), thymol (8.42%) and carvacrol (9.43%). After the experimental period, necropsy of the animals was accomplished, and macroscopic alterations were not observed in the tissues of the reproductive and digestive systems, as well as in liver, spleen and kidneys. The clinical, hematological and histopathological evaluation didn’t demonstrate any alteration. According to the results, the O. vulgare essential oil 3 %, when administered orally and intravaginal, during 30 days in Wistar rats, is not responsible for toxicological alterations. Other studies using O. vulgare oils with different terpenes concentrations are necessary. Reproductive toxicity investigations are also necessary." @default.
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• W1480612043 date "2008-01-01" @default.
• W1480612043 modified "2023-09-28" @default.
• W1480612043 title "Toxicidade pré-clínica em doses repetidas do óleo essencial do Origanum vulgare L. (Orégano) em ratas Wistar" @default.
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