FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1480657811> ?p ?o ?g. }

• W1480657811 abstract "The human cerebral cortex consists of approximately 1010 neurons that are organized into a complex network of local circuits and long-range connections. During the past years there has been an increasing interest from the neuro-scientific community towards the study of this network, referred to as the human connectome. Due to its ability to probe the tissue microstructure in vivo and non invasively, diffusion MRI has revealed to be a helpful tool for the analysis of brain axonal pathways at the millimeter scale. Whereas the neuronal level remains unreachable, diffusion MRI enables the mapping of a low-resolution estimate of the human connectome, which should give a new breath to the study of normal or pathologic neuroanatomy. After a short introduction on diffusion MRI and tractography, the process by which fiber tracts are reconstructed from the diffusion images, we present a methodology allowing the creation of normalized whole-brain structural connection matrices derived from tractography and representing the human connectome. Based on the developed framework we then investigate the potential of front propagation algorithms in tractography. We compare their performance with classical tractography approaches on several well-known associative fiber pathways, and we discuss their advantages and limitations. Several solutions are proposed in order to evaluate and validate the connectome-related methodology. We develop a method to estimate the respective contributions of diffusion contrast versus other effects to a tractography result. Using this methodology, we show that whereas we can have a strong confidence in mid- and long-range connections, short-range connectivity has to be interpreted with care. Next, we demonstrate the strong relationship between the structural connectivity obtained from diffusion MR tractography and the functional connectivity measured with functional MRI. Then, we compare the performance of several diffusion MRI techniques through connectome-based measurements. We find that diffusion spectrum imaging is more sensitive and therefore enhances the results of tractography. Finally, we present two network-oriented applications. We use the human connectome to reveal the small-world architecture of the brain, a very efficient network topology in terms of wiring and power supply. We identify the cortical areas that belong to the core of structural connectivity. We show that these regions also belong to the default mode network, a set of dynamically coupled brain regions that are found to be more highly activated at rest. As a conclusion, we emphasize the potential of human connectome mapping for clinical applications and pathological studies." @default.
• W1480657811 created "2016-06-24" @default.
• W1480657811 creator A5087392239 @default.
• W1480657811 date "2009-01-01" @default.
• W1480657811 modified "2023-09-23" @default.
• W1480657811 title "Global brain connectivity analysis by diffusion MR tractography" @default.
• W1480657811 doi "https://doi.org/10.5075/epfl-thesis-4511" @default.
• W1480657811 hasPublicationYear "2009" @default.
• W1480657811 type Work @default.
• W1480657811 sameAs 1480657811 @default.
• W1480657811 citedByCount "0" @default.
• W1480657811 crossrefType "journal-article" @default.
• W1480657811 hasAuthorship W1480657811A5087392239 @default.
• W1480657811 hasConcept C126838900 @default.
• W1480657811 hasConcept C143409427 @default.
• W1480657811 hasConcept C149550507 @default.
• W1480657811 hasConcept C153180895 @default.
• W1480657811 hasConcept C154945302 @default.
• W1480657811 hasConcept C15744967 @default.
• W1480657811 hasConcept C169760540 @default.
• W1480657811 hasConcept C2777670902 @default.
• W1480657811 hasConcept C2779097318 @default.
• W1480657811 hasConcept C3018011982 @default.
• W1480657811 hasConcept C41008148 @default.
• W1480657811 hasConcept C45715564 @default.
• W1480657811 hasConcept C71924100 @default.
• W1480657811 hasConcept C84787856 @default.
• W1480657811 hasConcept C97820695 @default.
• W1480657811 hasConceptScore W1480657811C126838900 @default.
• W1480657811 hasConceptScore W1480657811C143409427 @default.
• W1480657811 hasConceptScore W1480657811C149550507 @default.
• W1480657811 hasConceptScore W1480657811C153180895 @default.
• W1480657811 hasConceptScore W1480657811C154945302 @default.
• W1480657811 hasConceptScore W1480657811C15744967 @default.
• W1480657811 hasConceptScore W1480657811C169760540 @default.
• W1480657811 hasConceptScore W1480657811C2777670902 @default.
• W1480657811 hasConceptScore W1480657811C2779097318 @default.
• W1480657811 hasConceptScore W1480657811C3018011982 @default.
• W1480657811 hasConceptScore W1480657811C41008148 @default.
• W1480657811 hasConceptScore W1480657811C45715564 @default.
• W1480657811 hasConceptScore W1480657811C71924100 @default.
• W1480657811 hasConceptScore W1480657811C84787856 @default.
• W1480657811 hasConceptScore W1480657811C97820695 @default.
• W1480657811 hasLocation W14806578111 @default.
• W1480657811 hasOpenAccess W1480657811 @default.
• W1480657811 hasPrimaryLocation W14806578111 @default.
• W1480657811 hasRelatedWork W1533661094 @default.
• W1480657811 hasRelatedWork W1598153459 @default.
• W1480657811 hasRelatedWork W1995923410 @default.
• W1480657811 hasRelatedWork W2014292780 @default.
• W1480657811 hasRelatedWork W2016288483 @default.
• W1480657811 hasRelatedWork W2091910928 @default.
• W1480657811 hasRelatedWork W2122609459 @default.
• W1480657811 hasRelatedWork W2152552783 @default.
• W1480657811 hasRelatedWork W2159208769 @default.
• W1480657811 hasRelatedWork W2162686834 @default.
• W1480657811 hasRelatedWork W2169239134 @default.
• W1480657811 hasRelatedWork W2248364736 @default.
• W1480657811 hasRelatedWork W2499751743 @default.
• W1480657811 hasRelatedWork W2580540391 @default.
• W1480657811 hasRelatedWork W2769385597 @default.
• W1480657811 hasRelatedWork W2805978657 @default.
• W1480657811 hasRelatedWork W3036670922 @default.
• W1480657811 hasRelatedWork W3104253003 @default.
• W1480657811 hasRelatedWork W3123947939 @default.
• W1480657811 hasRelatedWork W3173306872 @default.
• W1480657811 isParatext "false" @default.
• W1480657811 isRetracted "false" @default.
• W1480657811 magId "1480657811" @default.
• W1480657811 workType "article" @default.