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- W1480677865 abstract "Peripheral blood and bone marrow mononuclear cells from 25 children with acute non-lymphoid leukaemia were analysed for natural killer cell activity and for cells with the Leu-7 and Leu-11b(CD 16) markers. Significantly reduced spontaneous cytotoxicity was detected in peripheral blood from children with untreated and active acute non-lymphoid leukaemia compared with that of the controls (P=0.01 and P<0.05). Patients to remission, however, had normal natural cytotoxicity and normal number of Leu-7 and Leu-11b(CD 16)-positive cells. The natural killer cell activity in hone marrow from patients with untreated acute non-lymphoid leukaemia was also significantly reduced (P=0.025). On die other hand, patients in remission had both an increased percentage of Leu-7 and Leu-11b (CD 16)-positive cells (P<0.05) and an increased natural killer cell activity (P<0.0005) in their bone marrow cells in comparison with the control group. This augmented natural killer cell activity is most probably a result of anti-leukaemic treatment. Stimulation with recombinant alpha interferon and recombinant interleukin 2 caused an increase in natural killer cell activity that was both significant and normal in both peripheral blood and bone marrow from children with acute non-lymphoid leukaemia." @default.
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- W1480677865 date "1988-07-01" @default.
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- W1480677865 title "Altered Natural Killer Cell Activity in Childhood Acute Non-lymphoid Leukaemia." @default.
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- W1480677865 doi "https://doi.org/10.1111/j.1365-3083.1988.tb02410.x" @default.
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