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• W1480690280 endingPage "1022" @default.
• W1480690280 startingPage "1002" @default.
• W1480690280 abstract "Summary Penicillium chrysogenum is the main industrial producer of the β‐lactam antibiotic penicillin, the most commonly used drug in the treatment of bacterial infections. Recently, a functional MAT 1‐1 locus encoding the α‐box transcription factor MAT 1‐1‐1 was discovered to control sexual development in P . chrysogenum . As only little was known from any organism about the regulatory functions mediated by MAT 1‐1‐1, we applied chromatin immunoprecipitation combined with next‐generation sequencing ( ChIP ‐seq) to gain new insights into the factors that influence MAT 1‐1‐1 functions on a molecular level and its role in genome‐wide transcriptional regulatory networks. Most importantly, our data provide evidence for mating‐type transcription factor functions that reach far beyond their previously understood role in sexual development. These new roles include regulation of hyphal morphology, asexual development, as well as amino acid, iron, and secondary metabolism. Furthermore, in vitro DNA –protein binding studies and downstream analysis in yeast and P . chrysogenum enabled the identification of a MAT 1‐1‐1 DNA ‐binding motif, which is highly conserved among euascomycetes. Our studies pave the way to a more general understanding of these master switches for development and metabolism in all fungi, and open up new options for optimization of fungal high production strains." @default.
• W1480690280 created "2016-06-24" @default.
• W1480690280 creator A5021457266 @default.
• W1480690280 creator A5024914337 @default.
• W1480690280 creator A5059042105 @default.
• W1480690280 creator A5067761628 @default.
• W1480690280 date "2015-03-28" @default.
• W1480690280 modified "2023-10-03" @default.
• W1480690280 title "Genome-wide identification of target genes of a mating-type α-domain transcription factor reveals functions beyond sexual development" @default.
• W1480690280 cites W1492436432 @default.
• W1480690280 cites W1518711517 @default.
• W1480690280 cites W1567386654 @default.
• W1480690280 cites W1582387945 @default.
• W1480690280 cites W1903792504 @default.
• W1480690280 cites W1967341601 @default.
• W1480690280 cites W1967651999 @default.
• W1480690280 cites W1969115614 @default.
• W1480690280 cites W1969799867 @default.
• W1480690280 cites W1971602185 @default.
• W1480690280 cites W1972315779 @default.
• W1480690280 cites W1972822540 @default.
• W1480690280 cites W1974901081 @default.
• W1480690280 cites W1979551779 @default.
• W1480690280 cites W1983852269 @default.
• W1480690280 cites W1984397663 @default.
• W1480690280 cites W1986342700 @default.
• W1480690280 cites W1986941949 @default.
• W1480690280 cites W1987201985 @default.
• W1480690280 cites W1987270409 @default.
• W1480690280 cites W1987622511 @default.
• W1480690280 cites W1991366896 @default.
• W1480690280 cites W1992678801 @default.
• W1480690280 cites W1996516710 @default.
• W1480690280 cites W2000119789 @default.
• W1480690280 cites W2002503145 @default.
• W1480690280 cites W2012035078 @default.
• W1480690280 cites W2014677321 @default.
• W1480690280 cites W2020465509 @default.
• W1480690280 cites W2024028338 @default.
• W1480690280 cites W2029895295 @default.
• W1480690280 cites W2030165987 @default.
• W1480690280 cites W2035282264 @default.
• W1480690280 cites W2035896334 @default.
• W1480690280 cites W2037112564 @default.
• W1480690280 cites W2042392223 @default.
• W1480690280 cites W2045362835 @default.
• W1480690280 cites W2045825275 @default.
• W1480690280 cites W2050252824 @default.
• W1480690280 cites W2058877429 @default.
• W1480690280 cites W2059699217 @default.
• W1480690280 cites W2064893599 @default.
• W1480690280 cites W2069058322 @default.
• W1480690280 cites W2069368388 @default.
• W1480690280 cites W2075889928 @default.
• W1480690280 cites W2076494331 @default.
• W1480690280 cites W2078114491 @default.
• W1480690280 cites W2079461029 @default.
• W1480690280 cites W2079771997 @default.
• W1480690280 cites W2081133825 @default.
• W1480690280 cites W2082155787 @default.
• W1480690280 cites W2084695584 @default.
• W1480690280 cites W2088512319 @default.
• W1480690280 cites W2093766978 @default.
• W1480690280 cites W2097220641 @default.
• W1480690280 cites W2097302864 @default.
• W1480690280 cites W2100674704 @default.
• W1480690280 cites W2101871915 @default.
• W1480690280 cites W2102836562 @default.
• W1480690280 cites W2103014023 @default.
• W1480690280 cites W2103777723 @default.
• W1480690280 cites W2108234281 @default.
• W1480690280 cites W2113134470 @default.
• W1480690280 cites W2114453819 @default.
• W1480690280 cites W2116673819 @default.
• W1480690280 cites W2117131162 @default.
• W1480690280 cites W2117599450 @default.
• W1480690280 cites W2118567456 @default.
• W1480690280 cites W2120772351 @default.
• W1480690280 cites W2121016320 @default.
• W1480690280 cites W2122097157 @default.
• W1480690280 cites W2123638539 @default.
• W1480690280 cites W2124080033 @default.
• W1480690280 cites W2124514674 @default.
• W1480690280 cites W2124927249 @default.
• W1480690280 cites W2124985265 @default.
• W1480690280 cites W2127189378 @default.
• W1480690280 cites W2131020279 @default.
• W1480690280 cites W2132304346 @default.
• W1480690280 cites W2137296022 @default.
• W1480690280 cites W2137917513 @default.
• W1480690280 cites W2138006485 @default.
• W1480690280 cites W2138907159 @default.
• W1480690280 cites W2139083403 @default.
• W1480690280 cites W2140741853 @default.
• W1480690280 cites W2140754446 @default.
• W1480690280 cites W2140913817 @default.
• W1480690280 cites W2140952049 @default.
• W1480690280 cites W2141573544 @default.

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