FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1480746327> ?p ?o ?g. }

• W1480746327 endingPage "e0127021" @default.
• W1480746327 startingPage "e0127021" @default.
• W1480746327 abstract "The cervicovaginal fluid (CVF) coating the vaginal epithelium is an important immunological mediator, providing a barrier to infection. Glycosylation of CVF proteins, such as mucins, IgG and S-IgA, plays a critical role in their immunological functions. Although multiple factors, such as hormones and microflora, may influence glycosylation of the CVF, few studies have examined their impact on this important immunological fluid. Herein we analyzed the glycosylation of cervicovaginal lavage (CVL) samples collected from 165 women under different hormonal conditions including: (1) no contraceptive, post-menopausal, (2) no contraceptive, days 1-14 of the menstrual cycle, (3) no contraceptive, days 15-28 of the menstrual cycle, (4) combined-oral contraceptive pills for at least 6 months, (5) depo-medroxyprogesterone acetate (Depo-Provera) injections for at least 6 months, (6) levonorgestrel IUD for at least 1 month. Glycomic profiling was obtained using our lectin microarray system, a rapid method to analyze carbohydrate composition. Although some small effects were observed due to hormone levels, the major influence on the glycome was the presence of an altered bacterial cohort due to bacterial vaginosis (BV). Compared to normal women, samples from women with BV contained lower levels of sialic acid and high-mannose glycans in their CVL. The change in high mannose levels was unexpected and may be related to the increased risk of HIV-infection observed in women with BV, as high mannose receptors are a viral entry pathway. Changes in the glycome were also observed with hormonal contraceptive use, in a contraceptive-dependent manner. Overall, microflora had a greater impact on the glycome than hormonal levels, and both of these effects should be more closely examined in future studies given the importance of glycans in the innate immune system." @default.
• W1480746327 created "2016-06-24" @default.
• W1480746327 creator A5017547539 @default.
• W1480746327 creator A5019707913 @default.
• W1480746327 creator A5047978114 @default.
• W1480746327 creator A5054522836 @default.
• W1480746327 creator A5055769408 @default.
• W1480746327 creator A5088789618 @default.
• W1480746327 date "2015-05-20" @default.
• W1480746327 modified "2023-09-23" @default.
• W1480746327 title "Studying the Effects of Reproductive Hormones and Bacterial Vaginosis on the Glycome of Lavage Samples from the Cervicovaginal Cavity" @default.
• W1480746327 cites W1565619760 @default.
• W1480746327 cites W1694178022 @default.
• W1480746327 cites W1717376330 @default.
• W1480746327 cites W1837922397 @default.
• W1480746327 cites W1868667984 @default.
• W1480746327 cites W187541409 @default.
• W1480746327 cites W1919484576 @default.
• W1480746327 cites W1965668376 @default.
• W1480746327 cites W1971683797 @default.
• W1480746327 cites W1980863117 @default.
• W1480746327 cites W1982782080 @default.
• W1480746327 cites W1987352082 @default.
• W1480746327 cites W1987484892 @default.
• W1480746327 cites W1988554751 @default.
• W1480746327 cites W1989010611 @default.
• W1480746327 cites W1990527526 @default.
• W1480746327 cites W2002356503 @default.
• W1480746327 cites W2007889846 @default.
• W1480746327 cites W2015716356 @default.
• W1480746327 cites W2017444821 @default.
• W1480746327 cites W2017939382 @default.
• W1480746327 cites W2019199044 @default.
• W1480746327 cites W2021799915 @default.
• W1480746327 cites W2022132405 @default.
• W1480746327 cites W2022687905 @default.
• W1480746327 cites W2024017427 @default.
• W1480746327 cites W2027959814 @default.
• W1480746327 cites W2028605145 @default.
• W1480746327 cites W2034740928 @default.
• W1480746327 cites W2036660182 @default.
• W1480746327 cites W2039486340 @default.
• W1480746327 cites W2043485602 @default.
• W1480746327 cites W2060386111 @default.
• W1480746327 cites W2074373284 @default.
• W1480746327 cites W2083618864 @default.
• W1480746327 cites W2084312540 @default.
• W1480746327 cites W2096605259 @default.
• W1480746327 cites W2098195379 @default.
• W1480746327 cites W2100668965 @default.
• W1480746327 cites W2101751324 @default.
• W1480746327 cites W2103226260 @default.
• W1480746327 cites W2104436843 @default.
• W1480746327 cites W2109471408 @default.
• W1480746327 cites W2110417357 @default.
• W1480746327 cites W2115059789 @default.
• W1480746327 cites W2123235973 @default.
• W1480746327 cites W2129351297 @default.
• W1480746327 cites W2131545113 @default.
• W1480746327 cites W2137237539 @default.
• W1480746327 cites W2140459452 @default.
• W1480746327 cites W2146307792 @default.
• W1480746327 cites W2148553882 @default.
• W1480746327 cites W2149523285 @default.
• W1480746327 cites W2150926065 @default.
• W1480746327 cites W2151678945 @default.
• W1480746327 cites W2152837700 @default.
• W1480746327 cites W2157461726 @default.
• W1480746327 cites W2159686118 @default.
• W1480746327 cites W2159787441 @default.
• W1480746327 cites W2161083892 @default.
• W1480746327 cites W2416119930 @default.
• W1480746327 cites W2466505982 @default.
• W1480746327 doi "https://doi.org/10.1371/journal.pone.0127021" @default.
• W1480746327 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4439148" @default.
• W1480746327 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25993513" @default.
• W1480746327 hasPublicationYear "2015" @default.
• W1480746327 type Work @default.
• W1480746327 sameAs 1480746327 @default.
• W1480746327 citedByCount "22" @default.
• W1480746327 countsByYear W14807463272015 @default.
• W1480746327 countsByYear W14807463272016 @default.
• W1480746327 countsByYear W14807463272017 @default.
• W1480746327 countsByYear W14807463272018 @default.
• W1480746327 countsByYear W14807463272019 @default.
• W1480746327 countsByYear W14807463272021 @default.
• W1480746327 countsByYear W14807463272022 @default.
• W1480746327 crossrefType "journal-article" @default.
• W1480746327 hasAuthorship W1480746327A5017547539 @default.
• W1480746327 hasAuthorship W1480746327A5019707913 @default.
• W1480746327 hasAuthorship W1480746327A5047978114 @default.
• W1480746327 hasAuthorship W1480746327A5054522836 @default.
• W1480746327 hasAuthorship W1480746327A5055769408 @default.
• W1480746327 hasAuthorship W1480746327A5088789618 @default.
• W1480746327 hasBestOaLocation W14807463271 @default.
• W1480746327 hasConcept C108625454 @default.
• W1480746327 hasConcept C126322002 @default.
• W1480746327 hasConcept C153911025 @default.

• next