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• W1480777921 abstract "Objectives To evaluate the performance of multiparametric magnetic resonance imaging ( mpMRI ) in predicting prostate cancer on repeat biopsy; and to compare the cancer detection rates ( CDR s) of MRI /transrectal ultrasonography ( TRUS ) fusion‐guided biopsy with standard 12‐core biopsy in men with at least one previous negative biopsy. Patients and Methods We prospectively enrolled men with elevated or rising PSA levels and/or abnormal digital rectal examination into our MRI / TRUS fusion‐guided prostate biopsy trial. Participants underwent a 3 T mpMRI with an endorectal coil. Three radiologists graded all suspicious lesions on a 5‐point Likert scale. MRI / TRUS fusion‐guided biopsies of suspicious prostate lesions and standard TRUS ‐guided 12‐core biopsies were performed. Analysis of 140 eligible men with at least one previous negative biopsy was performed. We calculated CDR s and estimated area under the receiver operating characteristic curves ( AUC s) of mpMRI in predicting any cancer and clinically significant prostate cancer. Results The overall CDR was 65.0% (91/140). Higher level of suspicion on mpMRI was significantly associated with prostate cancer detection ( P < 0.001) with an AUC of 0.744 compared with 0.653 and 0.680 for PSA level and PSA density, respectively. The CDR s of MRI / TRUS fusion‐guided and standard 12‐core biopsy were 52.1% (73/140) and 48.6% (68/140), respectively ( P = 0.435). However, fusion biopsy was more likely to detect clinically significant prostate cancer when compared with the 12‐core biopsy (47.9% vs 30.7%; P < 0.001). Of the cancers missed by 12‐core biopsy, 20.9% (19/91) were clinically significant. Most cancers missed by 12‐core biopsy (69.6%) were located in the anterior fibromuscular stroma and transition zone. Using a fusion‐biopsy‐only approach in men with an MRI suspicion score of ≥4 would have missed only 3.5% of clinically significant prostate cancers. Conclusions Using mpMRI and subsequent MRI / TRUS fusion‐guided biopsy platform may improve detection of clinically significant prostate cancer in men with previous negative biopsies. Addition of a 12‐core biopsy may be needed to avoid missing some clinically significant prostate cancers." @default.
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• W1480777921 date "2015-03-25" @default.
• W1480777921 modified "2023-10-04" @default.
• W1480777921 title "In patients with a previous negative prostate biopsy and a suspicious lesion on magnetic resonance imaging, is a 12-core biopsy still necessary in addition to a targeted biopsy?" @default.
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• W1480777921 doi "https://doi.org/10.1111/bju.12938" @default.
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