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- W1480854490 abstract "Abstract Seizures are a prominent clinical feature of encephalitis. Recent data suggest the adaptive as well as innate immune system to be involved directly in the pathomechanism of epileptogenesis. Cytotoxic T‐cells and antibody‐mediated complement activation are major components of the adaptive immune system, which can induce neurodegeneration, thereby probably contributing to epileptic encephalitis. The innate immune system operates via interleukin‐1 and toll‐like receptor‐associated mechanisms and was shown to play a direct role in epileptogenesis. Here, we review neuropathology hallmarks of various encephalitis conditions such as Rasmussen encephalitis (RE) but also introduce the more recently discovered antibody‐associated voltage‐gated potassium channel complex (VGKC), N‐methyl‐D‐aspartate receptor (NMDAR) or glutamic acid decarboxylase (GAD) 65 encephalitides. Neuropathological investigations are used to determine specific cellular components and molecular mechanisms used by the immune system to provoke neurodegeneration and to promote epileptogenesis. Based on recent findings, we propose concepts for the stratification of epileptic encephalitis. Knowledge of the role of the innate immunity has already translated into clinical treatment strategies and may help to discover novel drug targets for these epileptic disorders." @default.
- W1480854490 created "2016-06-24" @default.
- W1480854490 creator A5003170013 @default.
- W1480854490 creator A5070101998 @default.
- W1480854490 creator A5074695558 @default.
- W1480854490 date "2012-04-12" @default.
- W1480854490 modified "2023-10-17" @default.
- W1480854490 title "Epileptic Encephalitis: The Role of the Innate and Adaptive Immune System" @default.
- W1480854490 cites W1480524175 @default.
- W1480854490 cites W1482709215 @default.
- W1480854490 cites W1489220471 @default.
- W1480854490 cites W1533919108 @default.
- W1480854490 cites W1545791350 @default.
- W1480854490 cites W1787988090 @default.
- W1480854490 cites W1890069367 @default.
- W1480854490 cites W1963682880 @default.
- W1480854490 cites W1965907445 @default.
- W1480854490 cites W1968420305 @default.
- W1480854490 cites W1970671647 @default.
- W1480854490 cites W1976056645 @default.
- W1480854490 cites W1976986452 @default.
- W1480854490 cites W1978375913 @default.
- W1480854490 cites W1981175379 @default.
- W1480854490 cites W1983073649 @default.
- W1480854490 cites W1983883744 @default.
- W1480854490 cites W1984132292 @default.
- W1480854490 cites W1985489478 @default.
- W1480854490 cites W1986756933 @default.
- W1480854490 cites W1991893050 @default.
- W1480854490 cites W1996510251 @default.
- W1480854490 cites W1999011928 @default.
- W1480854490 cites W2000632431 @default.
- W1480854490 cites W2002426329 @default.
- W1480854490 cites W2008550860 @default.
- W1480854490 cites W2013918392 @default.
- W1480854490 cites W2013953370 @default.
- W1480854490 cites W2018653121 @default.
- W1480854490 cites W2019288807 @default.
- W1480854490 cites W2021639860 @default.
- W1480854490 cites W2022981588 @default.
- W1480854490 cites W2026436291 @default.
- W1480854490 cites W2028092193 @default.
- W1480854490 cites W2028332032 @default.
- W1480854490 cites W2029368857 @default.
- W1480854490 cites W2029679183 @default.
- W1480854490 cites W2030434347 @default.
- W1480854490 cites W2033242795 @default.
- W1480854490 cites W2038400236 @default.
- W1480854490 cites W2038446367 @default.
- W1480854490 cites W2041129046 @default.
- W1480854490 cites W2041525670 @default.
- W1480854490 cites W2042829577 @default.
- W1480854490 cites W2044577279 @default.
- W1480854490 cites W2045890664 @default.
- W1480854490 cites W2046500575 @default.
- W1480854490 cites W2046890475 @default.
- W1480854490 cites W2048275998 @default.
- W1480854490 cites W2048977435 @default.
- W1480854490 cites W2049455313 @default.
- W1480854490 cites W2050032735 @default.
- W1480854490 cites W2051552021 @default.
- W1480854490 cites W2052931950 @default.
- W1480854490 cites W2055215683 @default.
- W1480854490 cites W2059143483 @default.
- W1480854490 cites W2061056490 @default.
- W1480854490 cites W2066158538 @default.
- W1480854490 cites W2072597173 @default.
- W1480854490 cites W2077429401 @default.
- W1480854490 cites W2078990452 @default.
- W1480854490 cites W2080685344 @default.
- W1480854490 cites W2082107657 @default.
- W1480854490 cites W2084014688 @default.
- W1480854490 cites W2084545955 @default.
- W1480854490 cites W2087982685 @default.
- W1480854490 cites W2089032704 @default.
- W1480854490 cites W2089494151 @default.
- W1480854490 cites W2091558814 @default.
- W1480854490 cites W2091787833 @default.
- W1480854490 cites W2092317826 @default.
- W1480854490 cites W2093762179 @default.
- W1480854490 cites W2098569132 @default.
- W1480854490 cites W2100252544 @default.
- W1480854490 cites W2101833790 @default.
- W1480854490 cites W2103046674 @default.
- W1480854490 cites W2114398221 @default.
- W1480854490 cites W2114935132 @default.
- W1480854490 cites W2117009915 @default.
- W1480854490 cites W2118067546 @default.
- W1480854490 cites W2121155292 @default.
- W1480854490 cites W2121260921 @default.
- W1480854490 cites W2123159874 @default.
- W1480854490 cites W2127043216 @default.
- W1480854490 cites W2127587930 @default.
- W1480854490 cites W2127990813 @default.
- W1480854490 cites W2129933060 @default.
- W1480854490 cites W2131446968 @default.
- W1480854490 cites W2131625303 @default.
- W1480854490 cites W2133423973 @default.