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- W14808551 abstract "Personalized medicine is the leading practical outcome of the Human Genome Project. It concerns the individualization of pharmacotherapy according to the unique genomic and proteomic information which underlies the individuality of each patient and each case of therapeutical intervention. Personalized medicine, once incorporated into the clinical setting, would allow patients to be treated with the most fitting medicines, according to their genetic and protein profiles. Thus, it is projected to improve drug safety and efficacy, which presently are far from being satisfactory and are the main causes for the rising costs to society from adverse drug reactions (ADRs). It is too early to forecast when personalized medicine will be truly accomplished, but the process has begun and is likely to keep progressing rapidly, as more knowledge about human genome variation and its relation to drug metabolism and drug–target interactions is realized. This chapter introduces the concept of personalized medicine and its historical background, outlines a few specific examples related to drug pharmacokinetics and pharmacodynamics, and lists the key barriers and optional solutions for its implementation in the clinic, including some ethical and societal aspects." @default.
- W14808551 created "2016-06-24" @default.
- W14808551 creator A5081024990 @default.
- W14808551 date "2007-01-01" @default.
- W14808551 modified "2023-09-27" @default.
- W14808551 title "Personalized Medicine" @default.
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- W14808551 doi "https://doi.org/10.1016/b0-08-045044-x/00008-0" @default.
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