FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1481020525> ?p ?o ?g. }

• W1481020525 endingPage "1514" @default.
• W1481020525 startingPage "1509" @default.
• W1481020525 abstract "Ran is a small GTP binding protein that was originally identified as a regulator of nucleocytoplasmic transport [1] and subsequently found to be important for spindle formation [2-5]. In mitosis, a gradient of Ran-GTP emanates from chromatin and diminishes toward spindle poles [6]. Ran-GTP promotes spindle self-organization through the release of importin-bound spindle assembly factors (SAFs), which stimulate microtubule (MT) nucleation and organization and regulate MT dynamics [7-9]. Although many SAFs are non-motile MT-associated proteins, such as NuMA, TPX2, and HURP [7, 10-12], Ran also controls motor proteins, including Kid and HSET/XCTK2 [13, 14]. The Kinesin-14 XCKT2 is important for spindle assembly and pole organization [15-20], and Ran-GTP is proposed to promote XCKT2 MT crosslinking activity by releasing importin α/β from a bipartite nuclear localization signal (NLS) located in the tail domain [14]. Here, we show that the Ran-GTP gradient spatially regulates XCTK2 within the spindle. A flattened Ran-GTP gradient blocked the ability of excess XCTK2 to stimulate bipolar spindle assembly and resulted in XCTK2-mediated bundling of free MTs. These effects required the XCTK2 tail, which promoted the motility of XCTK2 within the spindle independent of the Ran-GTP gradient. In addition, the turnover kinetics of XCTK2 were spatially controlled: they were faster near the poles relative to the chromatin, but not with a mutant XCTK2 that cannot bind to importin α/β. Our results support a model in which the Ran-GTP gradient spatially coordinates motor localization with motility to ensure efficient spindle formation." @default.
• W1481020525 created "2016-06-24" @default.
• W1481020525 creator A5001699031 @default.
• W1481020525 creator A5005422746 @default.
• W1481020525 creator A5021147939 @default.
• W1481020525 creator A5026183598 @default.
• W1481020525 creator A5079932260 @default.
• W1481020525 creator A5088027601 @default.
• W1481020525 date "2015-06-01" @default.
• W1481020525 modified "2023-09-28" @default.
• W1481020525 title "The Ran-GTP Gradient Spatially Regulates XCTK2 in the Spindle" @default.
• W1481020525 cites W1569667199 @default.
• W1481020525 cites W1606409542 @default.
• W1481020525 cites W1966723276 @default.
• W1481020525 cites W1970897399 @default.
• W1481020525 cites W1988333558 @default.
• W1481020525 cites W1991690400 @default.
• W1481020525 cites W1992280291 @default.
• W1481020525 cites W1995190241 @default.
• W1481020525 cites W1997284260 @default.
• W1481020525 cites W1998634995 @default.
• W1481020525 cites W1999081109 @default.
• W1481020525 cites W2014977510 @default.
• W1481020525 cites W2020487525 @default.
• W1481020525 cites W2025753616 @default.
• W1481020525 cites W2029225125 @default.
• W1481020525 cites W2033062977 @default.
• W1481020525 cites W2036760739 @default.
• W1481020525 cites W2064062498 @default.
• W1481020525 cites W2091045865 @default.
• W1481020525 cites W2106243159 @default.
• W1481020525 cites W2111406540 @default.
• W1481020525 cites W2121696619 @default.
• W1481020525 cites W2130217713 @default.
• W1481020525 cites W2132655928 @default.
• W1481020525 cites W2134605133 @default.
• W1481020525 cites W2143997493 @default.
• W1481020525 cites W2149249386 @default.
• W1481020525 cites W2154782261 @default.
• W1481020525 cites W2162800498 @default.
• W1481020525 cites W2163754862 @default.
• W1481020525 cites W2170896050 @default.
• W1481020525 cites W2359181950 @default.
• W1481020525 cites W255772229 @default.
• W1481020525 doi "https://doi.org/10.1016/j.cub.2015.04.015" @default.
• W1481020525 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4452415" @default.
• W1481020525 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25981788" @default.
• W1481020525 hasPublicationYear "2015" @default.
• W1481020525 type Work @default.
• W1481020525 sameAs 1481020525 @default.
• W1481020525 citedByCount "28" @default.
• W1481020525 countsByYear W14810205252015 @default.
• W1481020525 countsByYear W14810205252016 @default.
• W1481020525 countsByYear W14810205252017 @default.
• W1481020525 countsByYear W14810205252018 @default.
• W1481020525 countsByYear W14810205252019 @default.
• W1481020525 countsByYear W14810205252020 @default.
• W1481020525 countsByYear W14810205252021 @default.
• W1481020525 countsByYear W14810205252022 @default.
• W1481020525 countsByYear W14810205252023 @default.
• W1481020525 crossrefType "journal-article" @default.
• W1481020525 hasAuthorship W1481020525A5001699031 @default.
• W1481020525 hasAuthorship W1481020525A5005422746 @default.
• W1481020525 hasAuthorship W1481020525A5021147939 @default.
• W1481020525 hasAuthorship W1481020525A5026183598 @default.
• W1481020525 hasAuthorship W1481020525A5079932260 @default.
• W1481020525 hasAuthorship W1481020525A5088027601 @default.
• W1481020525 hasBestOaLocation W14810205251 @default.
• W1481020525 hasConcept C10447061 @default.
• W1481020525 hasConcept C118716 @default.
• W1481020525 hasConcept C12554922 @default.
• W1481020525 hasConcept C133882971 @default.
• W1481020525 hasConcept C1491633281 @default.
• W1481020525 hasConcept C160704184 @default.
• W1481020525 hasConcept C181199279 @default.
• W1481020525 hasConcept C2780114586 @default.
• W1481020525 hasConcept C2780723820 @default.
• W1481020525 hasConcept C29537977 @default.
• W1481020525 hasConcept C47432576 @default.
• W1481020525 hasConcept C55493867 @default.
• W1481020525 hasConcept C58207958 @default.
• W1481020525 hasConcept C59157529 @default.
• W1481020525 hasConcept C70547292 @default.
• W1481020525 hasConcept C85813293 @default.
• W1481020525 hasConcept C86803240 @default.
• W1481020525 hasConcept C94921385 @default.
• W1481020525 hasConcept C95444343 @default.
• W1481020525 hasConceptScore W1481020525C10447061 @default.
• W1481020525 hasConceptScore W1481020525C118716 @default.
• W1481020525 hasConceptScore W1481020525C12554922 @default.
• W1481020525 hasConceptScore W1481020525C133882971 @default.
• W1481020525 hasConceptScore W1481020525C1491633281 @default.
• W1481020525 hasConceptScore W1481020525C160704184 @default.
• W1481020525 hasConceptScore W1481020525C181199279 @default.
• W1481020525 hasConceptScore W1481020525C2780114586 @default.
• W1481020525 hasConceptScore W1481020525C2780723820 @default.
• W1481020525 hasConceptScore W1481020525C29537977 @default.
• W1481020525 hasConceptScore W1481020525C47432576 @default.

• next