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- W1481058276 abstract "Background: Uveal melanoma arises from melanocytes in the uveal tract of the eye and is biologically different from cutaneous melanoma due to different genetic alterations and a propensity to metastasize to the liver. We hypothesize that growth factors synthesized in liver can play a significant role in this preferential homing of uveal melanoma metastasis. It is critical to explore the factors that can contribute to liver metastasis and identify targets. Further exploring the means to blocking them in a timely fashion is of high therapeutic value. IGF-1 (insulin like growth factor -1) and HGF (hepatocyte growth factor) are two major growth factors secreted from liver. The corresponding receptors, c-Met and IGF-1R have been detected in uveal melanoma tumors and also high protein expression was shown to be associated with poor survival. Therefore we initiated a study to determine the level of serum IGF-1 and HGF at sequential time points for primary and metastatic uveal melanoma patients, with the aim to test for correlation with clinical outcomes. Methods: Commercially available ELISA kits (Quantikine ELISA kits from RD Sep 20-23, 2014; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(14 Suppl):Abstract nr A27." @default.
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- W1481058276 date "2015-07-15" @default.
- W1481058276 modified "2023-09-25" @default.
- W1481058276 title "Abstract A27: Analyses of the level of liver borne growth factors, IGF-1 and HGF in metastatic and non-metastatic uveal melanoma patient serum: Correlation with outcome" @default.
- W1481058276 doi "https://doi.org/10.1158/1538-7445.mel2014-a27" @default.
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