FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1481103413> ?p ?o ?g. }

• W1481103413 abstract "Abstract Background The human immunodeficiency virus type 1 (HIV-1) nucleocapsid (NC) plays a pivotal role in the viral lifecycle: including encapsulating the viral genome, aiding in strand transfer during reverse transcription, and packaging two copies of the viral genome into progeny virions. Another gag gene product, p6, plays an integral role in successful viral budding from the plasma membrane and inclusion of the accessory protein Vpr within newly budding virions. In this study, we have characterized the gag NC and p6 genes from six mother-infant pairs following vertical transmission by performing phylogenetic analysis and by analyzing the degree of genetic diversity, evolutionary dynamics, and conservation of functional domains. Results Phylogenetic analysis of 168 gag NC and p6 genes sequences revealed six separate subtrees that corresponded to each mother-infant pair, suggesting that epidemiologically linked individuals were closer to each other than epidemiologically unlinked individuals. A high frequency (92.8%) of intact open reading frames of NC and p6 with patient and pair specific sequence motifs were conserved in mother-infant pairs' sequences. Nucleotide and amino acid distances showed a lower degree of viral heterogeneity, and a low degree of estimates of genetic diversity was also found in NC and p6 sequences. The NC and p6 sequences from both mothers and infants were found to be under positive selection pressure. The two important functional motifs within NC, the zinc-finger motifs, were highly conserved in most of the sequences, as were the gag p6 Vpr binding, AIP1 and late binding domains. Several CTL recognition epitopes identified within the NC and p6 genes were found to be mostly conserved in 6 mother-infant pairs' sequences. Conclusion These data suggest that the gag NC and p6 open reading frames and functional domains were conserved in mother-infant pairs' sequences following vertical transmission, which confirms the critical role of these gene products in the viral lifecycle." @default.
• W1481103413 created "2016-06-24" @default.
• W1481103413 creator A5051931242 @default.
• W1481103413 creator A5052322770 @default.
• W1481103413 creator A5070515856 @default.
• W1481103413 creator A5087480223 @default.
• W1481103413 date "2006-04-06" @default.
• W1481103413 modified "2023-09-23" @default.
• W1481103413 title "Molecular characterization of the HIV-1 gagnucleocapsid gene associated with vertical transmission" @default.
• W1481103413 cites W1517394695 @default.
• W1481103413 cites W1547922948 @default.
• W1481103413 cites W1557341781 @default.
• W1481103413 cites W1592797533 @default.
• W1481103413 cites W1601671592 @default.
• W1481103413 cites W1641947900 @default.
• W1481103413 cites W1831506252 @default.
• W1481103413 cites W1860192217 @default.
• W1481103413 cites W1923186253 @default.
• W1481103413 cites W1966880904 @default.
• W1481103413 cites W1978141733 @default.
• W1481103413 cites W1981548028 @default.
• W1481103413 cites W1987537050 @default.
• W1481103413 cites W1989929122 @default.
• W1481103413 cites W1993452562 @default.
• W1481103413 cites W1993877052 @default.
• W1481103413 cites W2009465113 @default.
• W1481103413 cites W2015057727 @default.
• W1481103413 cites W2016738212 @default.
• W1481103413 cites W2023420720 @default.
• W1481103413 cites W2032991359 @default.
• W1481103413 cites W2033320393 @default.
• W1481103413 cites W2043010257 @default.
• W1481103413 cites W2047515341 @default.
• W1481103413 cites W2056548409 @default.
• W1481103413 cites W2059841928 @default.
• W1481103413 cites W2063175211 @default.
• W1481103413 cites W2065822908 @default.
• W1481103413 cites W2069243230 @default.
• W1481103413 cites W2077470072 @default.
• W1481103413 cites W2082928585 @default.
• W1481103413 cites W2084197987 @default.
• W1481103413 cites W2089129669 @default.
• W1481103413 cites W2095331952 @default.
• W1481103413 cites W2100121370 @default.
• W1481103413 cites W2100488258 @default.
• W1481103413 cites W2102426911 @default.
• W1481103413 cites W2108287388 @default.
• W1481103413 cites W2123460928 @default.
• W1481103413 cites W2124061807 @default.
• W1481103413 cites W2125105872 @default.
• W1481103413 cites W2126760736 @default.
• W1481103413 cites W2126781708 @default.
• W1481103413 cites W2130448025 @default.
• W1481103413 cites W2133585817 @default.
• W1481103413 cites W2142614240 @default.
• W1481103413 cites W2142635246 @default.
• W1481103413 cites W2146667353 @default.
• W1481103413 cites W2147787558 @default.
• W1481103413 cites W2149401677 @default.
• W1481103413 cites W2151682372 @default.
• W1481103413 cites W2157513005 @default.
• W1481103413 cites W2160612361 @default.
• W1481103413 cites W2160622088 @default.
• W1481103413 cites W2162607594 @default.
• W1481103413 cites W2165728709 @default.
• W1481103413 cites W2167566575 @default.
• W1481103413 cites W2172708696 @default.
• W1481103413 cites W2172979631 @default.
• W1481103413 cites W2177206906 @default.
• W1481103413 cites W2180347587 @default.
• W1481103413 cites W2325626233 @default.
• W1481103413 doi "https://doi.org/10.1186/1742-4690-3-21" @default.
• W1481103413 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1459197" @default.
• W1481103413 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16600029" @default.
• W1481103413 hasPublicationYear "2006" @default.
• W1481103413 type Work @default.
• W1481103413 sameAs 1481103413 @default.
• W1481103413 citedByCount "16" @default.
• W1481103413 countsByYear W14811034132012 @default.
• W1481103413 countsByYear W14811034132013 @default.
• W1481103413 countsByYear W14811034132015 @default.
• W1481103413 countsByYear W14811034132016 @default.
• W1481103413 countsByYear W14811034132017 @default.
• W1481103413 crossrefType "journal-article" @default.
• W1481103413 hasAuthorship W1481103413A5051931242 @default.
• W1481103413 hasAuthorship W1481103413A5052322770 @default.
• W1481103413 hasAuthorship W1481103413A5070515856 @default.
• W1481103413 hasAuthorship W1481103413A5087480223 @default.
• W1481103413 hasBestOaLocation W14811034131 @default.
• W1481103413 hasConcept C104317684 @default.
• W1481103413 hasConcept C141231307 @default.
• W1481103413 hasConcept C159047783 @default.
• W1481103413 hasConcept C159654299 @default.
• W1481103413 hasConcept C193252679 @default.
• W1481103413 hasConcept C195616568 @default.
• W1481103413 hasConcept C24284526 @default.
• W1481103413 hasConcept C54355233 @default.
• W1481103413 hasConcept C6881719 @default.
• W1481103413 hasConcept C70721500 @default.
• W1481103413 hasConcept C86339819 @default.

• next