Matches in SemOpenAlex for { <https://semopenalex.org/work/W1481111703> ?p ?o ?g. }
- W1481111703 endingPage "567" @default.
- W1481111703 startingPage "556" @default.
- W1481111703 abstract "Many papers have introduced adaptive clinical trial methods that allow modifications to the sample size based on interim estimates of treatment effect. There has been extensive commentary on type I error control and efficiency considerations, but little research on estimation after an adaptive hypothesis test. We evaluate the reliability and precision of different inferential procedures in the presence of an adaptive design with pre-specified rules for modifying the sampling plan. We extend group sequential orderings of the outcome space based on the stage at stopping, likelihood ratio statistic, and sample mean to the adaptive setting in order to compute median-unbiased point estimates, exact confidence intervals, and P-values uniformly distributed under the null hypothesis. The likelihood ratio ordering is found to average shorter confidence intervals and produce higher probabilities of P-values below important thresholds than alternative approaches. The bias adjusted mean demonstrates the lowest mean squared error among candidate point estimates. A conditional error-based approach in the literature has the benefit of being the only method that accommodates unplanned adaptations. We compare the performance of this and other methods in order to quantify the cost of failing to plan ahead in settings where adaptations could realistically be pre-specified at the design stage. We find the cost to be meaningful for all designs and treatment effects considered, and to be substantial for designs frequently proposed in the literature." @default.
- W1481111703 created "2016-06-24" @default.
- W1481111703 creator A5054672758 @default.
- W1481111703 creator A5075875570 @default.
- W1481111703 creator A5090993994 @default.
- W1481111703 date "2014-04-25" @default.
- W1481111703 modified "2023-10-14" @default.
- W1481111703 title "An evaluation of inferential procedures for adaptive clinical trial designs with pre-specified rules for modifying the sample size" @default.
- W1481111703 cites W1480884888 @default.
- W1481111703 cites W1964458952 @default.
- W1481111703 cites W1972286219 @default.
- W1481111703 cites W1976597504 @default.
- W1481111703 cites W1985729969 @default.
- W1481111703 cites W1986502618 @default.
- W1481111703 cites W2001556361 @default.
- W1481111703 cites W2004275808 @default.
- W1481111703 cites W2007994516 @default.
- W1481111703 cites W2009790176 @default.
- W1481111703 cites W2019159505 @default.
- W1481111703 cites W2020526475 @default.
- W1481111703 cites W2029932873 @default.
- W1481111703 cites W2041674025 @default.
- W1481111703 cites W2045512772 @default.
- W1481111703 cites W2048935051 @default.
- W1481111703 cites W2053990449 @default.
- W1481111703 cites W2059131751 @default.
- W1481111703 cites W2059707463 @default.
- W1481111703 cites W2068784681 @default.
- W1481111703 cites W2069607843 @default.
- W1481111703 cites W2080979030 @default.
- W1481111703 cites W2087417641 @default.
- W1481111703 cites W2088238660 @default.
- W1481111703 cites W2090824711 @default.
- W1481111703 cites W2094617805 @default.
- W1481111703 cites W2119190259 @default.
- W1481111703 cites W2127151679 @default.
- W1481111703 cites W2150459557 @default.
- W1481111703 cites W2317137046 @default.
- W1481111703 cites W2331139255 @default.
- W1481111703 doi "https://doi.org/10.1111/biom.12168" @default.
- W1481111703 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24766094" @default.
- W1481111703 hasPublicationYear "2014" @default.
- W1481111703 type Work @default.
- W1481111703 sameAs 1481111703 @default.
- W1481111703 citedByCount "8" @default.
- W1481111703 countsByYear W14811117032014 @default.
- W1481111703 countsByYear W14811117032017 @default.
- W1481111703 countsByYear W14811117032019 @default.
- W1481111703 countsByYear W14811117032020 @default.
- W1481111703 countsByYear W14811117032021 @default.
- W1481111703 countsByYear W14811117032022 @default.
- W1481111703 crossrefType "journal-article" @default.
- W1481111703 hasAuthorship W1481111703A5054672758 @default.
- W1481111703 hasAuthorship W1481111703A5075875570 @default.
- W1481111703 hasAuthorship W1481111703A5090993994 @default.
- W1481111703 hasBestOaLocation W14811117032 @default.
- W1481111703 hasConcept C105795698 @default.
- W1481111703 hasConcept C129848803 @default.
- W1481111703 hasConcept C142724271 @default.
- W1481111703 hasConcept C166957645 @default.
- W1481111703 hasConcept C169857963 @default.
- W1481111703 hasConcept C191988596 @default.
- W1481111703 hasConcept C2776957806 @default.
- W1481111703 hasConcept C2982777018 @default.
- W1481111703 hasConcept C33923547 @default.
- W1481111703 hasConcept C40696583 @default.
- W1481111703 hasConcept C41008148 @default.
- W1481111703 hasConcept C41426520 @default.
- W1481111703 hasConcept C44249647 @default.
- W1481111703 hasConcept C535046627 @default.
- W1481111703 hasConcept C71924100 @default.
- W1481111703 hasConcept C87007009 @default.
- W1481111703 hasConcept C89128539 @default.
- W1481111703 hasConcept C95457728 @default.
- W1481111703 hasConceptScore W1481111703C105795698 @default.
- W1481111703 hasConceptScore W1481111703C129848803 @default.
- W1481111703 hasConceptScore W1481111703C142724271 @default.
- W1481111703 hasConceptScore W1481111703C166957645 @default.
- W1481111703 hasConceptScore W1481111703C169857963 @default.
- W1481111703 hasConceptScore W1481111703C191988596 @default.
- W1481111703 hasConceptScore W1481111703C2776957806 @default.
- W1481111703 hasConceptScore W1481111703C2982777018 @default.
- W1481111703 hasConceptScore W1481111703C33923547 @default.
- W1481111703 hasConceptScore W1481111703C40696583 @default.
- W1481111703 hasConceptScore W1481111703C41008148 @default.
- W1481111703 hasConceptScore W1481111703C41426520 @default.
- W1481111703 hasConceptScore W1481111703C44249647 @default.
- W1481111703 hasConceptScore W1481111703C535046627 @default.
- W1481111703 hasConceptScore W1481111703C71924100 @default.
- W1481111703 hasConceptScore W1481111703C87007009 @default.
- W1481111703 hasConceptScore W1481111703C89128539 @default.
- W1481111703 hasConceptScore W1481111703C95457728 @default.
- W1481111703 hasIssue "3" @default.
- W1481111703 hasLocation W14811117031 @default.
- W1481111703 hasLocation W14811117032 @default.
- W1481111703 hasLocation W14811117033 @default.
- W1481111703 hasOpenAccess W1481111703 @default.
- W1481111703 hasPrimaryLocation W14811117031 @default.