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- W1481191915 abstract "Publisher Summary This chapter describes expression of gastric MUC5AC mucin during colon carcinogenesis. The originality of these monoclonal antibodies (MAbs) is the unusual method of the selection of hybridomas secreting anti-M1 antibodies. Using immunohistology, ones selected the clones secreting antibodies that showed on serial sections the same immunostaining pattern as the polyclonal anti-M1 antibodies: strong staining of colonic adenomatous glands and normal surface gastric epithelium but negative on the normal colon. When the complete sequence of the MUC5AC gene became available, it was possible to show that 8 of these 11 anti-gastric M1 MAbs immunoreacted with the product of this MUC5AC gene. The epitopes recognized by the three other MAbs were precipitated by each of eight anti-M1/MUC5AC MAbs that immunoreacted with the product of MUC5AC gene. Consequently, the link between gastric M1 mucin and the MUC5AC gene was clearly established. Secretory mucins may be regarded also as specific differentiation markers for each of the mucous cells of the digestive epithelium. This last characteristic is of importance to study the modifications of cell differentiation during the carcinogenesis processes. Thus, these mucins can also be of interest as potential tumor markers." @default.
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- W1481191915 date "2002-01-01" @default.
- W1481191915 modified "2023-09-27" @default.
- W1481191915 title "6 Expression of gastric MUC5AC mucin during colon carcinogenesis" @default.
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- W1481191915 doi "https://doi.org/10.1016/s1874-5784(02)80022-8" @default.
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