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- W1481308183 abstract "Objective There is emerging evidence that the microRNA-146a (miR-146a) rs2910164 polymorphism might be associated with the susceptibility to colorectal cancer (CRC). However, previous published studies have failed to achieve a definitive conclusion. We aimed to address this issue in an updated meta-analysis. Methods A comprehensive literature search was conducted in PubMed, Embase, China BioMedicine, the Cochrane Library and Google Scholar to identify eligible studies. Case-control studies written in English that evaluated the association between miR-146a polymorphism and CRC were included. Odds ratio and 95% confidence interval were calculated in the quantitative synthesis. Results Overall seven case-control studies including a total of 2978 cases and 3576 cancer-free or healthy controls were enrolled in the meta-analysis. The results indicated that there was no association between miR-146a G/C rs2910164 polymorphism and CRC risk either in the overall analysis or among Asians, when stratified on the basis of ethnicity. Conclusion miR-146a G/C genetic polymorphism was not related to the susceptibility to CRC." @default.
- W1481308183 created "2016-06-24" @default.
- W1481308183 creator A5029607409 @default.
- W1481308183 creator A5037373375 @default.
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- W1481308183 date "2014-12-01" @default.
- W1481308183 modified "2023-09-26" @default.
- W1481308183 title "Effect of a common genetic variant microRNA-146a rs2910164 on colorectal cancer: A meta-analysis" @default.
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- W1481308183 doi "https://doi.org/10.1111/1751-2980.12201" @default.
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