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• W1481319827 abstract "<b><i>Background:</i></b> Evidence as to the benefits of nonpharmacological interventions for the boundary state between normal aging and dementia [mild cognitive impairment or a Clinical Dementia Rating (CDR) of 0.5] remains weak due to a lack of positive controls. <b><i>Aims:</i></b> To directly compare the effects of cognitive interventions (CI), physical activities (PA) and a group reminiscence approach (GRA), we conducted a pilot study on the basis of a cluster randomized controlled trial design. <b><i>Method:</i></b> A total of 127 participants aged >74 years with a CDR of 0.5 were cluster randomized into three groups for CI, PA and GRA. The intervention lasted 12 weeks and consisted of weekly group sessions and home assignments. Mini-Mental State Examination (MMSE), Trail Making Test part A (TMT-A), word fluency (WF), 6-meter walk time and Quality of Life (QOL) Face Scale scores were evaluated as primary outcomes. <b><i>Results:</i></b> Methodology-related benefits of CI and PA were found for MMSE scores and walk time, respectively. TMT-A, WF and QOL Face Scale scores improved irrespective of the methodologies used. <b><i>Conclusions:</i></b> Our findings suggest that CI and PA may be beneficial to cognitive and physical abilities, respectively. Executive functions and QOL may improve irrespective of the intervention methodologies used." @default.
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• W1481319827 date "2015-05-30" @default.
• W1481319827 modified "2023-09-27" @default.
• W1481319827 title "A Cluster Randomized Controlled Trial of Nonpharmacological Interventions for Old-Old Subjects with a Clinical Dementia Rating of 0.5: The Kurihara Project" @default.
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• W1481319827 doi "https://doi.org/10.1159/000380816" @default.
• W1481319827 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4483494" @default.
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