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- W1481361569 abstract "Publisher Summary This chapter discusses the molecular mode of action of cytotoxic alkaloids. Alkaloids comprise a class of secondary metabolites. Alkaloids have evolved in plants as powerful defence compounds against herbivores. Although many of them interfere with neuroreceptors and neuronal signal transduction, several others have cytotoxic properties, directed against animal and microbial cells. The chapter summarizes some of the molecular targets that are involved in this process. Alkaloids that interfere with microtubules, with DNA (intercalation, topoisomerase inhibition), with protein biosynthesis, and with membrane stability, apparently induce apoptosis, thus leading to cell death. Because of the evolutionary selection processes, one can conclude that alkaloids and other SM produced by plants, animals, and microbes could be relevant molecules when searching for bioactive compounds against new drug targets. Many cytotoxic compounds, such as pyrroles, pyrazines, imidazoles, and other N-heterocyclic alkaloids, have been discovered in marine organisms, such as sponges, ascidians, tunicates, and molluscs; several have been tested as novel antitumor agents. In order to discover interesting active compounds from nature, one only have to search by selecting the appropriate organisms and using intelligent screening assays, including high throughput procedures." @default.
- W1481361569 created "2016-06-24" @default.
- W1481361569 creator A5034011528 @default.
- W1481361569 date "2007-01-01" @default.
- W1481361569 modified "2023-10-10" @default.
- W1481361569 title "Chapter 1 Molecular Modes of Action of Cytotoxic Alkaloids: From DNA Intercalation, Spindle Poisoning, Topoisomerase Inhibition to Apoptosis and Multiple Drug Resistance" @default.
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