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- W1481626775 abstract "A theoretical treatment of growth and disassembly of focal adhesions is developed in the framework of rate processes driven by thermodynamics. For this purpose, the structural unit of focal adhesions is a complex consisting of a ligand such as fibronectin, an integrin molecule, and associated plaque proteins. The free energy that drives binding and dissociation of the complexes includes mechanical, chemical and statistical (mixing entropy) contributions. The binding and dissociation of complexes manifests as growth and disassembly, respectively, of focal adhesions. We have complemented fracture mechanics by bond formation to explain this reversible chemo-mechanical process. The reaction-limited case is considered. We have identified a competition between four mechanisms: (i) mechanical work done by actin-transmitted force, (ii) a chemical instability inherent to focal adhesions, (iii) an elastic instability, and (iv) a molecular conformational change, that control focal adhesion dynamics. Our central finding is that for a focal adhesion to slide requires symmetry breaking between its two ends. This happens only with the first of these four mechanisms. The molecular conformational change can contribute symmetric growth modes, while the remaining two mechanisms cause disassembly." @default.
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- W1481626775 date "2009-10-15" @default.
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- W1481626775 title "A Theoretical Study of the Thermodynamics and Kinetics of Focal Adhesion Dynamics" @default.
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- W1481626775 doi "https://doi.org/10.1007/978-90-481-3348-2_15" @default.
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